Mody G M, Meyers O L
Department of Medicine, University of Cape Town.
S Afr Med J. 1988 Jan 9;73(1):55-6.
A 22-year-old woman with active seronegative rheumatoid arthritis responded to intramuscular gold but developed proteinuria which settled when this therapy was stopped. Proteinuria recurred after 2 weeks of penicillamine therapy but settled when this regimen was stopped. Six months later she developed a nephrotic syndrome and rectal and renal biopsies showed evidence of amyloidosis. She was treated with chlorambucil for 1 year and the disease activity was well controlled. There was regression of the nephrotic syndrome and her serum albumin and renal function are normal 6 years later.
一名22岁的血清阴性类风湿关节炎活动期女性对肌肉注射金制剂有反应，但出现了蛋白尿，停用该疗法后蛋白尿消失。青霉胺治疗2周后蛋白尿复发，但停用该治疗方案后蛋白尿又消失。6个月后，她发展为肾病综合征，直肠和肾活检显示有淀粉样变性的证据。她接受了苯丁酸氮芥治疗1年，疾病活动得到了很好的控制。肾病综合征有所缓解，6年后她的血清白蛋白和肾功能正常。
