一种靶向脂滴的荧光探针，可用于高效的肾癌光动力学治疗的图像引导。
A lipid droplet targeted fluorescent probe for high-efficiency image-guided photodynamic therapy of renal cell carcinoma.
机构信息
Department of Urology, Institute of Urology, Huaxi MR Research Center (HMRRC), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 37 Guoxue Road, Chengdu 610064, P. R. China.
出版信息
Chem Commun (Camb). 2021 Jan 25;57(8):1046-1049. doi: 10.1039/d0cc07336a. Epub 2021 Jan 7.
A one-step synthesized LD specific fluorescent probe TTIE with high specificity, good photostability and great capacity in generating cytotoxic reactive oxygen species (ROS) under low powered white light irradiation is designed and synthesized for LD specific image-guided photodynamic therapy (PDT) in human clear cell renal cell carcinoma (ccRCC) primary cells and tissues.
设计并合成了一种一步合成的 LD 特异性荧光探针 TTIE，该探针具有高特异性、良好的光稳定性和在低功率白光照射下产生细胞毒性活性氧 (ROS) 的能力，用于人肾透明细胞癌细胞 (ccRCC) 原代细胞和组织中 LD 特异性的图像引导光动力治疗 (PDT)。
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