Lozoya X, Romero G, Olmedo M, Bondani A
Arch Invest Med (Mex). 1977;8(2):145-54.
The hypnotic properties of leaves and seed of Casimiroa edulis (zapote blanco) a tropical fruit, are well known. In the present investigation, pharmacological studies on aqueous and alcoholic extracts were carried out in dogs, cats, rabbits and guinea pigs, using different experimental models. The action of the extracts upon blood pressure, cardiac activity, respiration rate, muscular tone, electroencephalographic activity, sleep and other parameters were studied too. In addition to, studies upon isolated human, cat, rabbit and guinea pig tissues gave information about the extracts effect on smooth muscle activity. It was found that both aqueous and alcoholic extract of the seed of zapote blanco produced marked hypotension in all animal species, which was followed by a sleep-like stage. Also a definitive oxitocic effect in vivo and in vitro was demonstrated suggesting the presence of a potent uterus constricting substance.
热带水果白柿（Casimiroa edulis）的叶子和种子具有催眠特性，这是广为人知的。在本研究中，使用不同的实验模型，对狗、猫、兔子和豚鼠进行了水提取物和醇提取物的药理学研究。还研究了提取物对血压、心脏活动、呼吸频率、肌肉张力、脑电图活动、睡眠及其他参数的作用。此外，对分离的人体、猫、兔子和豚鼠组织的研究提供了有关提取物对平滑肌活动影响的信息。结果发现，白柿种子的水提取物和醇提取物在所有动物物种中均产生明显的低血压，随后进入类似睡眠的阶段。还在体内和体外证实了明确的催产作用，表明存在一种有效的子宫收缩物质。
