García González M, Freer Bustamante E, Morales Matamoros O
Departamento de Fisiología, Escuela de Medicina, Universidad de Costa Rica.
Rev Biol Trop. 1994 Apr-Aug;42(1-2):115-9.
Aqueous extracts of Casimiroa edulis leaves injected intravenously to 20 normal Sprague-Dawley rats produced a rapid and transitory increase in blood pressure. The amplitude of the blood pressure rise was dose dependent. The increase was statistically significant (p < or = 0.01) at a concentration of 220 mOsm/l, and was associated with a significant heart rate decrease (p < or = 0.01) probably secondary to barorreceptor stimuli. The application of 130 mOsm/l of the extract did not produce a significant increase in blood pressure, which was followed by a rapid pressure normalization. The slight increase in cardiac rate during the pressure lift was probably due to sympathetic stimuli.
将甜果樟叶片的水提取物静脉注射到20只正常的斯普拉格-道利大鼠体内，可使血压迅速短暂升高。血压升高的幅度呈剂量依赖性。在浓度为220毫渗摩尔/升时，血压升高具有统计学意义（p≤0.01），并且伴有心率显著下降（p≤0.01），这可能继发于压力感受器刺激。应用130毫渗摩尔/升的提取物未使血压显著升高，随后血压迅速恢复正常。血压升高期间心率略有增加可能是由于交感神经刺激。
