Hypertension Unit (ESH Excellence Center), Department of Internal Medicine, University Hospital of Heraklion, Stavrakia and Voutes Crossroads, 71110, Heraklion, Crete, Greece.
Hormones (Athens). 2021 Jun;20(2):377-380. doi: 10.1007/s42000-020-00266-y. Epub 2021 Jan 6.
PURPOSE/OBJECTIVE: While hypertension is an important contributor to cardiovascular disease (CVD) and its treatment has well-established mortality benefits, there is uncertainty as regards the management of isolated systolic hypertension (ISH). Furthermore, the association of ISH with CVD and mortality has been established, but the metabolic characteristics of the affected population have not as yet been adequately described. The aim of this study was to describe the metabolic profiles of patients with ISH.
An observational study of patients attending the Hypertension Unit of the University Hospital of Heraklion, Crete, Greece, was performed.
In total, 809 hypertensive patients not on any antihypertensive treatment were identified. Among them, 44.7% were men, aged 55.6 ± 12.5 years, while 29.7% of both men and women were smokers. Systolic blood pressure was 161.3 ± 15.8 mmHg and diastolic blood pressure was 96.1 ± 11.3 mmHg. Body mass index (BMI) was 31 ± 5.3 kg/m, while 9.6% had type 2 diabetes (T2D). A comparison of patients with ISH with those with hypertension, but not ISH, revealed that patients with ISH were older and had lower SBP and higher pulse pressure, while they also had lower total cholesterol and LDL and were more likely to have T2D, albeit they had a slightly lower BMI. On the other hand, they did not have any difference in terms of gender, smoking status, HDL, triglycerides, liver biochemistry, uric acid, or prevalence of impaired fasting glucose.
Patients with ISH were older, with lower SBP, total cholesterol, and LDL and higher pulse pressure and higher prevalence of diabetes.
虽然高血压是心血管疾病（CVD）的重要致病因素，其治疗已被证实具有明确的降低死亡率的益处，但对于单纯收缩期高血压（ISH）的治疗仍存在不确定性。此外，ISH 与 CVD 和死亡率之间的关联已得到确立，但受影响人群的代谢特征尚未得到充分描述。本研究旨在描述 ISH 患者的代谢特征。
对希腊克里特岛伊拉克利翁大学医院高血压科的患者进行了一项观察性研究。
共确定了 809 名未接受任何降压治疗的高血压患者。其中，44.7%为男性，年龄 55.6±12.5 岁，29.7%的男性和女性为吸烟者。收缩压为 161.3±15.8mmHg，舒张压为 96.1±11.3mmHg。体重指数（BMI）为 31±5.3kg/m²，9.6%的患者患有 2 型糖尿病（T2D）。将 ISH 患者与无 ISH 的高血压患者进行比较发现，ISH 患者年龄较大，收缩压和脉压较低，而总胆固醇和 LDL 水平较高，且更有可能患有 T2D，尽管其 BMI 略低。另一方面，两组患者在性别、吸烟状况、HDL、甘油三酯、肝功能、尿酸或空腹血糖受损的发生率方面没有差异。
ISH 患者年龄较大，收缩压、总胆固醇和 LDL 水平较低，脉压较高，糖尿病患病率较高。
