Galletti P M, Aebischer P, Sasken H F, Goddard M B, Chiu T H
Artificial Organ Laboratory, Brown University, Providence, RI 02912.
Surgery. 1988 Feb;103(2):231-41.
Reorganization of the arterial wall through natural processes on the resorption of a totally bioresorbable graft was investigated in dogs with Vicryl prostheses coated with two different blends of bioresorbable polyesters capable of slowing down considerably the disintegration of a Vicryl fabric in vivo. The prostheses (8 to 9 mm in internal diameter, 8 to 10 cm long) were implanted in the infrarenal aortic position for up to 24 weeks. All 18 animals implanted with coated prostheses survived, whereas one animal implanted with an uncoated Vicryl prosthesis died because of early rupture of the graft. Patent tubular conduits were present in 14 animals at the time of retrieval. On resorption of the synthetic polymers, the tissue layers that formed on both sides of the prosthetic material either fused or remained separated, depending on the polymer used as a retardant coating. We conclude that polymer composition influences the repair process and that a fully resorbable vascular graft can function effectively in a canine model, provided that tissue organization is sufficiently advanced by the time the prosthesis has lost its mechanical integrity. Further studies are needed to document the performance of the newly formed blood conduit over extended periods, in hypertensive subjects, and when presented with a bacterial challenge.
在犬类动物中，研究了使用涂覆有两种不同生物可吸收聚酯混合物的薇乔假体时，完全生物可吸收移植物吸收过程中动脉壁通过自然过程的重组情况，这两种混合物能够显著减缓薇乔织物在体内的分解。将内径为8至9毫米、长8至10厘米的假体植入肾下腹主动脉位置长达24周。所有18只植入涂覆假体的动物均存活，而1只植入未涂覆薇乔假体的动物因移植物早期破裂死亡。在取出时，14只动物体内存在通畅的管状导管。随着合成聚合物的吸收，根据用作延迟涂层的聚合物不同，在假体材料两侧形成的组织层要么融合，要么保持分离。我们得出结论，聚合物组成会影响修复过程，并且只要在假体失去机械完整性时组织组织化足够成熟，完全可吸收的血管移植物就能在犬类模型中有效发挥作用。需要进一步研究以记录新形成的血管导管在高血压患者中、长时间以及面临细菌挑战时的性能。
