Rice Research Institute, Sichuan Agricultural University, 211, Huimin Road, Wenjiang District, Chengdu, 611130, Sichuan, China.
Department of Botany, Faculty of Life Sciences, University of Okara, Okara, 56130, Pakistan.
Environ Sci Pollut Res Int. 2021 Apr;28(16):20023-20033. doi: 10.1007/s11356-020-11854-1. Epub 2021 Jan 6.
Cadmium (Cd) is an element injurious for human health and is possibly toxic to organisms at minor concentrations. While some of other trace metallic elements have antagonistic features to it. One of them is the interaction between selenium (Se) and Cd in plant different organs. Literature review disclosed that the intake of Se to some extent can reduce the accumulation of Cd in plants, while the research on of trace metallic elements (Cd) and Se-enriched food (rice) in the living body has rarely been reported. This study intended to explore whether there was a mitigating effect of Se-enriched rice on mice poisoned with Cd. A mouse model of low-dose and high-dose Cd poisoning was established (supplemented with cadmium chloride(CdCl·2½H0)), followed by feeding two groups (1) Se-enriched rice and (2) setting an equal amount of inorganic Se group. After that, the impact of Se-enriched rice on the antioxidant activity was evaluated. The Se-enriched diet enhanced the total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and enzyme activities of GSH peroxidase (GSH-Px) in mice livers and kidney whereas significantly decreased the malondialdehyde (MDA) contents. Moreover, the degree of physiological damage in mice with low cadmium poisoning was significantly alleviated, and the expression of antioxidant genes (Nrf-2, GPX1, TrxR2, TNF-2) was increased. In conclusion, the Se-enriched diet has a positive effect on the biological effects in mice, and it can be used as a daily diet to resist damage to the body's low Cd state and support enzymatic antioxidant systems by eliminating oxidative injury.
镉 (Cd) 对人体健康有害，即使在低浓度下也可能对生物体有毒。虽然其他一些痕量金属元素对其具有拮抗作用。其中之一是硒 (Se) 和 Cd 在植物不同器官中的相互作用。文献综述表明，摄入适量的 Se 可以在一定程度上减少植物对 Cd 的积累，而关于痕量金属元素 (Cd) 和富硒食品 (大米) 在体内的研究则很少有报道。本研究旨在探讨富硒大米是否对 Cd 中毒的小鼠有缓解作用。建立了低剂量和高剂量 Cd 中毒的小鼠模型（补充氯化镉 (CdCl·2½H0)），然后分别喂食两组（1）富硒大米和（2）等量无机 Se 组。之后，评估富硒大米对抗氧化活性的影响。富硒饮食增强了小鼠肝脏和肾脏中的总抗氧化能力 (T-AOC)、超氧化物歧化酶 (SOD) 和谷胱甘肽过氧化物酶 (GSH-Px) 的酶活性，同时显著降低了丙二醛 (MDA) 的含量。此外，低 Cd 中毒小鼠的生理损伤程度得到显著缓解，抗氧化基因 (Nrf-2、GPX1、TrxR2、TNF-2) 的表达增加。总之，富硒饮食对小鼠的生物学效应有积极影响，可作为日常饮食，抵抗机体低 Cd 状态下的损伤，通过消除氧化损伤来支持酶抗氧化系统。
