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Nonspecific Binding Considerations in the Rational Design and Development of Small Molecule COVID-19 Therapeutics.

作者信息

Maurer Tristan S

机构信息

Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts, USA.

出版信息

Clin Pharmacol Ther. 2021 Aug;110(2):294-296. doi: 10.1002/cpt.2159. Epub 2021 Feb 5.

DOI:10.1002/cpt.2159
PMID:33410139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8359223/
Abstract
摘要

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本文引用的文献

1
Toward Consensus on Correct Interpretation of Protein Binding in Plasma and Other Biological Matrices for COVID-19 Therapeutic Development.关于在 COVID-19 治疗开发中正确解释血浆和其他生物基质中蛋白结合的共识。
Clin Pharmacol Ther. 2021 Jul;110(1):64-68. doi: 10.1002/cpt.2099. Epub 2020 Nov 21.
2
Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19.具有潜在重新用于靶向 COVID-19 能力的现有高积累溶酶体靶向药物。
Biomed Pharmacother. 2020 Oct;130:110582. doi: 10.1016/j.biopha.2020.110582. Epub 2020 Jul 30.
3
Does In Vitro Potency Predict Clinically Efficacious Concentrations?体外效力能否预测临床有效浓度?
Clin Pharmacol Ther. 2020 Aug;108(2):298-305. doi: 10.1002/cpt.1846. Epub 2020 May 10.
4
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.洛匹那韦-利托那韦治疗成人重症 COVID-19 患者的临床试验。
N Engl J Med. 2020 May 7;382(19):1787-1799. doi: 10.1056/NEJMoa2001282. Epub 2020 Mar 18.
5
Dose Predictions for Drug Design.药物设计中的剂量预测。
J Med Chem. 2020 Jun 25;63(12):6423-6435. doi: 10.1021/acs.jmedchem.9b01365. Epub 2020 Jan 22.
6
Importance of target-mediated drug disposition for small molecules.小分子药物靶标介导处置的重要性。
Drug Discov Today. 2018 Dec;23(12):2023-2030. doi: 10.1016/j.drudis.2018.06.010. Epub 2018 Jun 19.
7
Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.深入了解肺部药物处置的当前进展:肺部药物转运体第一次研讨会会议纪要
J Pharm Sci. 2017 Sep;106(9):2234-2244. doi: 10.1016/j.xphs.2017.04.011. Epub 2017 Apr 15.
8
Volume of Distribution in Drug Design.药物设计中的分布容积。
J Med Chem. 2015 Aug 13;58(15):5691-8. doi: 10.1021/acs.jmedchem.5b00201. Epub 2015 Apr 1.
9
Do we need to optimize plasma protein and tissue binding in drug discovery?在药物研发中,我们是否需要优化血浆蛋白和组织结合?
Curr Top Med Chem. 2011;11(4):450-66. doi: 10.2174/156802611794480918.
10
The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery.血浆蛋白结合对体内疗效的影响:药物发现中的误解。
Nat Rev Drug Discov. 2010 Dec;9(12):929-39. doi: 10.1038/nrd3287.