Tang Dongxin, Huang Wei, Yang Zhu, Wu Xin, Sang Xianan, Wang Kuilong, Cao Gang, Hao Min
Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
J Biochem Mol Toxicol. 2021 Apr;35(4):e22703. doi: 10.1002/jbt.22703. Epub 2021 Jan 6.
The purpose of this paper is to investigate the immune function of the tumor microenvironment and its clinical correlation with colonic carcinoma. Immune genes were downloaded from the The Cancer Genome Atlas database. Five subtypes are obtained by cluster screening based on immune gene expression data. The C3 and C4 subtypes show stronger immune activity. In addition, the C4 subtype has the largest number of gene mutations and the worst prognosis. Most of the immune signatures are upregulated in the C4 subtype, while most of the immune infiltration-related cells are upregulated in the C3 and C4 subtypes. The different immune microenvironments between these subtypes may provide new ideas for immunotherapy strategies in colon carcinoma.
本文旨在研究肿瘤微环境的免疫功能及其与结肠癌的临床相关性。免疫基因从癌症基因组图谱数据库下载。基于免疫基因表达数据通过聚类筛选获得五个亚型。C3和C4亚型显示出更强的免疫活性。此外，C4亚型具有最多的基因突变且预后最差。大多数免疫特征在C4亚型中上调，而大多数免疫浸润相关细胞在C3和C4亚型中上调。这些亚型之间不同的免疫微环境可能为结肠癌的免疫治疗策略提供新思路。
