Masui T, Shirai T, Imaida K, Uwagawa S, Fukushima S
First Department of Pathology, Nagoya City University Medical School, Japan.
Toxicol Lett. 1988 Feb;40(2):119-26. doi: 10.1016/0378-4274(88)90152-x.
In order to examine the promoting effect of urinary crystals on urinary bladder carcinogenesis, acetazolamide, uracil, and diethylene glycol, all of which have been reported to cause urinary crystals or calculi, were administered to male F344 rats for 32 weeks after pretreatment with 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 weeks. A marked increase in urinary crystals was observed in acetazolamide-treated rats and a slight increase in crystals was observed in uracil- and diethylene glycol-treated rats. Histological examination of the urinary bladder revealed that the BBN-acetazolamide treatment resulted in a higher incidence of carcinoma than BBN-control. Uracil and diethylene glycol did not cause any significant difference compared to the control. Promoting effects by urinary crystals were not clearly shown in the present experiment and, therefore, urinary crystals appear to play a very limited role, if any, in urinary bladder carcinogenesis.
为了研究尿结晶对膀胱致癌作用的促进效果，在雄性F344大鼠经4周0.05% N-丁基-N-(4-羟基丁基)亚硝胺（BBN）预处理后，给予已报道可导致尿结晶或结石的乙酰唑胺、尿嘧啶和二甘醇，持续32周。在乙酰唑胺处理的大鼠中观察到尿结晶显著增加，在尿嘧啶和二甘醇处理的大鼠中观察到结晶略有增加。膀胱组织学检查显示，BBN-乙酰唑胺处理组的癌发生率高于BBN对照组。与对照组相比，尿嘧啶和二甘醇未引起任何显著差异。在本实验中未明确显示尿结晶的促进作用，因此，尿结晶在膀胱致癌作用中似乎只起非常有限的作用（如果有作用的话）。
