Inagaki M, Miura T, Taki M, Saito N, Yamada K, Unuma T, Tsuda F, Miyakawa Y, Mayumi M
Department of Pediatrics, Keio University, Tokyo, Japan.
Transfusion. 1988 Jan-Feb;28(1):18-20. doi: 10.1046/j.1537-2995.1988.28188127943.x.
Two hundred two patients with hemophilia, dependent solely on imported coagulation factor concentrates, were tested for markers of hepatitis B virus infection, antibody to hepatitis delta virus (anti-HD), and antibody to human immunodeficiency virus (anti-HIV). Nine carriers of hepatitis B surface antigen (HBsAg) were identified. Six (66.7%) of them were positive for anti-HD, a prevalence much higher than that in HBsAg carriers without hemophilia in Japan (1/113 or 0.9%, p less than 0.001). Anti-HIV was found in 96 (47.5%), in sharp contrast to the low prevalence (0/1205) in apparently healthy blood donors (p less than 0.001). These results implicated imported plasma products in the transmission of both delta and human immunodeficiency viruses to hemophiliacs. An efficient method for the sterilization of plasma products is warranted to prevent exposure of hemophiliacs to the accompanying pathogenic viruses.
对仅依赖进口凝血因子浓缩物的202例血友病患者进行了乙肝病毒感染标志物、丁型肝炎病毒抗体（抗-HD）和人类免疫缺陷病毒抗体（抗-HIV）检测。确定了9例乙肝表面抗原（HBsAg）携带者。其中6例（66.7%）抗-HD呈阳性，这一患病率远高于日本无血友病的HBsAg携带者（1/113或0.9%，p<0.001）。96例（47.5%）检测出抗-HIV，这与表面健康的献血者中低患病率（0/1205）形成鲜明对比（p<0.001）。这些结果表明进口血浆制品将丁型和人类免疫缺陷病毒传播给了血友病患者。有必要采用一种有效的血浆制品消毒方法，以防止血友病患者接触伴随的致病病毒。
