Food Phytochemistry Department, Instituto de la Grasa (C.S.I.C.), Campus Universidad Pablo de Olavide, Carretera de Utrera Km 1, 41089, Sevilla, Spain.
Departamento de Ingeniería Agroindustrial, Universidad Autónoma Chapingo, Km. 38.5 Carretera México-Texcoco, 56230, Chapingo, Estado de México, Mexico.
Chem Biodivers. 2021 Feb;18(2):e2000827. doi: 10.1002/cbdv.202000827. Epub 2021 Jan 7.
Vicia palaestina Boiss. is an annual herb that grows in dry areas of eastern Mediterranean countries. It belongs to section Cracca subgenus Vicilla, which is characterized by having a high content in the non-protein amino acid canavanine. The seeds from some of these vetches are also rich in lectins. The purification and characterization of a single-chain lectin from the seeds of V. palaestina is described here. This lectin was the most abundant protein in albumin extracts. It has affinity for the glycoconjugate N-acetylgalactosamine and inhibits proliferation of the cancerous Caco-2 and THP-1 cell lines. In addition to their high nutritional value, the seeds from V. palaestina represent a source of lectins with health promoting and pharmacological potential because of their antiproliferative activity.
巴勒斯坦野豌豆（Vicia palaestina Boiss.）是一种一年生草本植物，生长在地中海东部国家的干旱地区。它属于节 Cracca 亚属 Vicilla，其特征是含有高含量的非蛋白氨基酸瓜氨酸。这些野豌豆的一些种子也富含凝集素。本文描述了从巴勒斯坦野豌豆种子中纯化和表征一种单链凝集素。这种凝集素是白蛋白提取物中最丰富的蛋白质。它对糖缀合物 N-乙酰半乳糖胺具有亲和力，并抑制癌细胞 Caco-2 和 THP-1 细胞系的增殖。除了具有高营养价值外，巴勒斯坦野豌豆的种子还是具有促进健康和药理学潜力的凝集素的来源，因为它们具有抗增殖活性。
