Department of Chemistry, School of Science, China Pharmaceutical University, Nanjing 211198, China.
Org Biomol Chem. 2021 Jan 28;19(4):785-788. doi: 10.1039/d0ob02404j. Epub 2021 Jan 7.
The enantioselective synthesis of 2-amino-4H-chromenes via the cascade rhodium-catalysed conjugate addition/hetero Thorpe-Ziegler reaction is reported. Moderate to good yields (up to 98%) and high enantioselectivities (up to 92% ee) were obtained with a chiral diene-coordinated rhodium complex as the catalyst. This protocol remedies the methodological deficiency in the asymmetric synthesis of 4-aryl 2-amino-4H-chromenes.
通过级联铑催化的共轭加成/杂 Thorpe-Ziegler 反应，报告了 2-氨基-4H-色烯的对映选择性合成。使用手性二烯配位的铑配合物作为催化剂，可获得中等至良好的收率（高达 98%）和高对映选择性（高达 92%ee）。该方案弥补了不对称合成 4-芳基 2-氨基-4H-色烯方法的缺陷。
