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破裂性血泡样动脉瘤:最佳治疗选择真的存在吗?

Ruptured blood blister like aneurysm: does the best therapeutic option really exist?

机构信息

Department of Neurosurgery, Lille University Hospital, rue E. Laine, 59037, Lille cedex, France.

Department of Neurosurgery, Saint-Etienne University Hospital, Saint-Priest-en-Jarez, France.

出版信息

Neurosurg Rev. 2021 Oct;44(5):2767-2775. doi: 10.1007/s10143-020-01463-4. Epub 2021 Jan 7.

Abstract

Our study aimed to evaluate the outcome of patients with ruptured blood-blister like aneurysm (BBLA) in our institution by comparing microsurgical selective treatment to endovascular treatment using flow-diverter stent (FD). Our study included 18 consecutive patients treated for BBLA between 2004 and 2020. Until 2014, microsurgery was preferred in all patients with BBLA (n = 10). Significant postoperative morbi-mortality was recorded at this time and led us to change therapeutic strategy and to favor FD as first-line treatment in all patients (n = 8). Postprocedural complications and BBLA occlusion were recorded. High WFNS score (> 2) was noted in 6 patients of microsurgical group and in 2 of endovascular group. In microsurgical group, ischemic lesions were noted in 6 patients and led to death in 3 patients. Immediate BBLA occlusion was obtained in all patients. Favorable outcome after 3 months (mRS < 3) was recorded in 4 of the 7 survivors. In endovascular group, ischemic lesions were noted in 4 patients. One patient died from early postprocedural BBLA rebleeding. Scarpa hematoma was noted in 3 patients with surgical evacuation in 1. Persistent BBLA at 3 months was recorded in 4 patients without rebleeding, but further FD was required in 1 with growing BBLA. Favorable outcome was noted in 6 of the 7 survivors. Although, rate of morbi-mortality appear lower in patients treated with FD, neurological presentation was better and BBLA diagnosis remains questionable in this group. Moreover, persistent BBLA imaging with potential risk of rebleeding after FD deserves to be discussed.

摘要

我们的研究旨在通过比较使用血流导向装置(FD)的血管内治疗和显微手术选择性治疗来评估我院破裂性血泡样动脉瘤(BBLA)患者的治疗效果。我们的研究纳入了 2004 年至 2020 年间连续治疗的 18 例 BBLA 患者。直到 2014 年,所有 BBLA 患者(n=10)均采用显微手术治疗。此时记录到显著的术后死亡率,并导致我们改变治疗策略,使 FD 成为所有患者的一线治疗(n=8)。记录了术后并发症和 BBLA 闭塞情况。显微手术组中有 6 例和血管内组中有 2 例 WFNS 评分较高(>2)。在显微手术组中,6 例患者出现缺血性病变,导致 3 例患者死亡。所有患者均立即获得 BBLA 闭塞。7 例幸存者中有 4 例在 3 个月后(mRS<3)预后良好。血管内组中,4 例患者出现缺血性病变。1 例患者死于术后早期 BBLA 再出血。3 例患者出现 Scarpa 血肿,其中 1 例进行了手术清除。4 例患者在 3 个月时仍存在 BBLA,但 1 例 BBLA 持续增大,需要进一步进行 FD。7 例幸存者中有 6 例预后良好。虽然接受 FD 治疗的患者死亡率较低,但神经表现较好,且该组患者的 BBLA 诊断仍存在疑问。此外,FD 后存在持续的 BBLA 影像学表现,有再出血的潜在风险,值得讨论。

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