Noonan Gregory O, Whelton Andrew J, Carlander David, Duncan Timothy V
Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, U.S.A.
Dept. of Civil Engineering, Univ. of South Alabama, 150 Jaguar Drive, Shelby Hall, Suite 3142, Mobile, AL 36688, U.S.A.
Compr Rev Food Sci Food Saf. 2014 Jul;13(4):679-692. doi: 10.1111/1541-4337.12079.
This article is one of a series of 4 that report on a task of the NanoRelease Food Additive project of the Intl. Life Science Inst. Center for Risk Science Innovation and Application to identify, evaluate, and develop methods that are needed to confidently detect, characterize, and quantify intentionally produced engineered nanomaterials (ENMs) released from food along the alimentary tract. This particular article focuses on the problem of detecting ENMs that become released into food indirectly from food contact materials. In this review, an in-depth analysis of the release literature is presented and relevant release mechanisms are discussed. The literature review includes discussion of articles related to the release phenomenon in general, as experimental methods to detect ENMs migrating from plastic materials into other (nonfood) complex matrices were determined to be relevant to the focus problem of food safety. From the survey of the literature, several "control points" were identified where characterization data on ENMs and materials may be most valuable. The article concludes with a summary of findings and a discussion of potential knowledge gaps and targets for method development in this area.
本文是系列4篇文章之一，报道了国际生命科学研究所风险科学创新与应用中心的纳米释放食品添加剂项目的一项任务，即识别、评估和开发可靠检测、表征和量化沿消化道从食品中释放的有意生产的工程纳米材料（ENM）所需的方法。这篇特定文章聚焦于检测从食品接触材料间接释放到食品中的ENM的问题。在本综述中，对释放文献进行了深入分析，并讨论了相关的释放机制。文献综述包括对一般与释放现象相关文章的讨论，因为检测ENM从塑料材料迁移到其他（非食品）复杂基质中的实验方法被确定与食品安全的重点问题相关。通过对文献的调查，确定了几个“控制点”，在这些点上ENM和材料的表征数据可能最有价值。文章最后总结了研究结果，并讨论了该领域潜在的知识空白和方法开发目标。
