选定的营养化合物在人癌细胞系中的体外抗增殖活性。
In vitro anti-proliferative activity of selected nutraceutical compounds in human cancer cell lines.
作者信息
Nibret Endalkachew, Krstin Sonja, Wink Michael
机构信息
Department of Biology, Science College, Bahir Dar University, P.O.Box 79, Bahir Dar, Ethiopia.
Biotechnology Research Institute, Bahir Dar University, P.O.Box 79, Bahir Dar, Ethiopia.
出版信息
BMC Res Notes. 2021 Jan 7;14(1):18. doi: 10.1186/s13104-020-05435-1.
OBJECTIVE
We investigated the anti-proliferative or cytotoxic activities of five nutraceutical compounds: allyl isothiocyanate, β-carotene, caffeine, capsaicin, and lupanine that we consume respectively, for example, from mustard seeds, carrot, coffee, pepper, and lupin seeds against cancer cell lines (human colon: HCT 116 p53 wild type, HCT 116 p53-/- and lymphoblastic: CEM/CCRF, CEM/ADR5000).
RESULT
Out of the five compounds tested in vitro, capsaicin and β-carotene were more cytotoxic than the other three compounds against the four cancer cell lines. The most potent nutraceutical compound was capsaicin and it exerted its highest cytotoxicity against HCT 116 p53-/- with IC value of 19.67 ± 0.06 µM. It is worth considering capsaicin for further development of anticancer drug against both colon and leukemia cancer types.
目的
我们研究了五种营养化合物的抗增殖或细胞毒性活性，这五种营养化合物分别是烯丙基异硫氰酸酯、β-胡萝卜素、咖啡因、辣椒素和羽扇豆碱，它们分别存在于我们食用的芥菜种子、胡萝卜、咖啡、胡椒和羽扇豆种子中，研究其对癌细胞系（人结肠癌细胞系：HCT 116 p53野生型、HCT 116 p53 -/-，以及淋巴细胞癌细胞系：CEM/CCRF、CEM/ADR5000）的作用。
结果
在体外测试的五种化合物中，辣椒素和β-胡萝卜素对四种癌细胞系的细胞毒性比其他三种化合物更强。最有效的营养化合物是辣椒素，它对HCT 116 p53 -/-细胞系的细胞毒性最高，IC值为19.67±0.06µM。值得考虑进一步开发以辣椒素为基础针对结肠癌和白血病类型的抗癌药物。
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