Hublikar Leena V, Ganachari Sharanabasava V, Patil Veerabhadragouda B, Nandi Sahana, Honnad Aishwarya
Center for Energy and Environment, School of Advanced Sciences, KLE Technological University, Hubballi, 580031, India.
Department of Chemistry and Research Centre, NMKRV College for Women, Bangaluru, 560011, India.
Prog Biomater. 2023 Jun;12(2):155-169. doi: 10.1007/s40204-023-00219-9. Epub 2023 Apr 24.
A Lantana camara leaf (LC) extract was used as a mild reducing agent to produce silver metal nanoparticles (LC-AgNPs) efficiently. The size, shape, and morphology of synthesized silver nanoparticles were verified. LC-AgNPs were found in LC extract by XRD. The optimal concentrations of silver nitrate and LC extract necessary for the production of stable silver nanoparticles were determined. The LC-AgNPs were found spherical in form and monodispersed. Under optimal conditions, the round LC-AgNPs of 50-90 nm were utilized to cure lung cancer (A549 cell line) and breast cancer (MCF7) cell lines. Finally, the produced LC-AgNPs enhanced anti-cancer efficacy against A549 cells, with an IC50 = 49.52 g/mL. Similarly, the effect of LC-AgNPs on MCF7 cell line was assessed using an MTT test and inhibitory concentration (IC50) was determined found that 46.67 g/mL.
马缨丹叶（LC）提取物被用作一种温和的还原剂，以高效地制备银金属纳米颗粒（LC-AgNPs）。对合成的银纳米颗粒的尺寸、形状和形态进行了验证。通过X射线衍射在LC提取物中发现了LC-AgNPs。确定了制备稳定银纳米颗粒所需的硝酸银和LC提取物的最佳浓度。发现LC-AgNPs呈球形且单分散。在最佳条件下，利用50-90纳米的圆形LC-AgNPs来治疗肺癌（A549细胞系）和乳腺癌（MCF7）细胞系。最后，所制备的LC-AgNPs增强了对A549细胞的抗癌功效，IC50 = 49.52微克/毫升。同样，使用MTT试验评估了LC-AgNPs对MCF7细胞系的作用，并确定其抑制浓度（IC50）为46.67微克/毫升。
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