表观遗传记忆：细菌持续存在的潜在驱动力？

Epigenetic Memories: The Hidden Drivers of Bacterial Persistence?

机构信息

Section of Microbial Ecology and Biotechnology, Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg, Denmark.

出版信息

Trends Microbiol. 2021 Mar;29(3):190-194. doi: 10.1016/j.tim.2020.12.005. Epub 2021 Jan 4.

DOI:10.1016/j.tim.2020.12.005

PMID:33414017

Abstract

Epigenetic modifications, including DNA methylation, stably alter gene expression without modifying genomic sequences. Recent evidence suggests that epigenetic regulation coupled with a long-term 'memory' effect plays a major role within bacterial persistence formation. Today, emerging high-resolution, single-molecule sequencing technologies allow an increased focus on DNA modifications as regulatory epigenetic marks, which presents a unique opportunity to identify possible epigenetic drivers of bacterial persistence.

摘要

表观遗传修饰，包括 DNA 甲基化，在不改变基因组序列的情况下稳定地改变基因表达。最近的证据表明，表观遗传调控与长期的“记忆”效应一起，在细菌持续存在的形成中发挥着重要作用。如今，新兴的高分辨率、单分子测序技术使得人们更加关注作为调控表观遗传标记的 DNA 修饰，这为确定细菌持续存在的可能表观遗传驱动因素提供了独特的机会。