Fulton A B, Hansen R M
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Am J Ophthalmol. 1988 Feb 15;105(2):132-40. doi: 10.1016/0002-9394(88)90175-4.
We used reflection retinal densitometric, psychophysical, and electroretinographic techniques to study the scotopic retinal function of a mother and her three daughters who had clinical evidence of a sectoral type of retinitis pigmentosa. Retinal regions with, and those without, ophthalmoscopic signs of degeneration were investigated. During dark adaptation, the time courses of rhodopsin regeneration and recovery of scotopic sensitivity were similar to normal as was the relation of rhodopsin to scotopic threshold. In dark-adapted eyes, threshold increases were not proportional to rhodopsin loss. The results of psychophysical tests of background adaptation and temporal summation, and analysis of the relation of electroretinographic a- to b-wave amplitudes, led to the conclusion that abnormalities of photoreceptor cell function central to the rhodopsin-bearing outer segments accounted for the increased thresholds.
我们运用视网膜反射密度测定法、心理物理学方法和视网膜电图技术，对一位母亲及其三个女儿的暗视视网膜功能进行了研究，她们都有扇形视网膜色素变性的临床证据。我们对有检眼镜下变性体征的视网膜区域和无此体征的区域进行了研究。在暗适应过程中，视紫红质再生和暗视敏感度恢复的时间进程与正常情况相似，视紫红质与暗视阈值的关系也是如此。在暗适应的眼睛中，阈值增加与视紫红质损失不成比例。背景适应和时间总和的心理物理学测试结果，以及视网膜电图a波与b波振幅关系的分析，得出结论：以含有视紫红质的外节为核心的光感受器细胞功能异常导致了阈值升高。
