The relation of rhodopsin and scotopic sensitivity in choroideremia.

We examined two patients who had clinical characteristics typical of choroideremia using psychophysical and reflection retinal densitometric techniques. In the dark-adapted state, sensitivity was more compromised than would be predicted on the basis of the modest losses of rhodopsin. In the dark-adapted state, studies of spatial and temporal summation suggested that postreceptoral processes are similar to normal. The kinetics of rhodopsin regeneration after bleaching exposures were abnormal in some retinal regions.