土耳其实施幼儿疫苗接种后甲型肝炎病毒的年龄特异性血清流行率：易感性向青少年转移。

Hepatitis A virus age-specific seroprevalence after the implementation of a Toddlers' Vaccination in Turkey: Shifting susceptibility to adolescents.

作者信息

Akman Alkım Öden, Burhan Başak Yalçın, Uzun Aysun Kara, Taş Demet

机构信息

Department of Pediatrics, University of Health Sciences, Ankara Child Health and Diseases Hematology and Oncology Training and Research Hospital, Ankara, Turkey.

Department of Medical Biology and Genetics, Gazi University Faculty of Medicine and Quality Management Unit, University of Health Sciences, Ankara Child Health and Diseases Hematology and Oncology Training and Research Hospital, Ankara, Turkey.

出版信息

Turk Pediatri Ars. 2020 Dec 16;55(4):370-375. doi: 10.14744/TurkPediatriArs.2020.06982. eCollection 2020.

DOI:10.14744/TurkPediatriArs.2020.06982

PMID:33414654

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7750331/

Abstract

AIM

In Turkey, improvements in sanitation and the implementation of a vaccination program resulted in reduced rates of childhood exposure to hepatitis A virus. The incidence of symptoms and the complications of the disease are known to be increased in later ages. We aimed to describe changes in the seroprevalence of hepatitis A virus from the pre-vaccine era (2012) to the post-vaccine era (2018) in different age groups.

MATERIAL AND METHODS

Levels of anti-hepatitis A virus immunoglobulin (Ig)-G of patients with no chronic disease and who were admitted to our hospital between 2013-2018 were obtained retrospectively from a single children's hospital database system.

RESULTS

A total of 3238 subjects were enrolled in the study (2820 children, 418 adults). The overall percentage of seropositivity was 60.5% in group 1 (age ≤2 years), 57.9% in group 2 (age 2-6 years), 31.2% in group 3 (age 7-11 years), 32.7% in group 4 (age 12-18 years), 44.6% in group 5 (age 19-24 years), and 73.9% in group 6 (age >25 years). Between 2013-2018, the increase in the number of seropositive individuals in group 2 (p<0.01), and the decrease in groups 3 and 4 were statistically significant from 2013 to 2018 (p=0.028, p<0.01).

CONCLUSION

According to the data of this single-center children's hospital in Turkey, hepatitis A virus seropositivity increases significantly in the preschool age group, but decreases in school-age children and adolescents after vaccination.

摘要

目的

在土耳其，卫生条件的改善和疫苗接种计划的实施降低了儿童接触甲型肝炎病毒的几率。已知该疾病的症状发生率和并发症在较高年龄段会增加。我们旨在描述不同年龄组从疫苗接种前时代（2012年）到疫苗接种后时代（2018年）甲型肝炎病毒血清阳性率的变化。

材料与方法

回顾性地从一个儿童医院数据库系统中获取了2013年至2018年间入住我院的无慢性病患者的抗甲型肝炎病毒免疫球蛋白（Ig）-G水平。

结果

共有3238名受试者纳入研究（2820名儿童，418名成人）。第1组（年龄≤2岁）血清阳性总体百分比为60.5%，第2组（年龄2 - 6岁）为57.9%，第3组（年龄7 - 11岁）为31.2%，第4组（年龄12 - 18岁）为3缉.7%，第5组（年龄19 - 24岁）为44.6%，第6组（年龄>25岁）为73.9%。2013年至2018年间，第2组血清阳性个体数量增加（p<0.01），第3组和第4组数量减少，2013年至2018年差异有统计学意义（p = 0.028，p<0.01）。