Cha Joon Min, Kim Dong Hyun, Subedi Lalita, Khan Zahra, Choi Sang Un, Kim Sun Yeou, Kim Chung Sub
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.
Beilstein J Org Chem. 2020 Dec 17;16:3078-3085. doi: 10.3762/bjoc.16.257. eCollection 2020.
A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (), was isolated from the twigs of together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher's method, and LC-MS analysis. The characterized compounds' biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.
从[植物名称]的嫩枝中通过色谱方法分离出一种新的巨大戟烷型降倍半萜糖苷，即chaemeloside（），同时还分离出11种已知的植物化学物质。通过常规的一维和二维核磁共振数据分析、电子圆二色谱实验、水解后采用改良的莫舍尔方法以及液相色谱-质谱分析确定了新分离物的化学结构。对所鉴定化合物的生物效应进行了评估，包括对癌细胞系的细胞毒性、抗神经炎症活性和潜在的神经营养作用。
