Kim Dong Hyun, Subedi Lalita, Kim Hye Ryeong, Choi Sang Un, Kim Sun Yeou, Kim Chung Sub
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Korea.
Antioxidants (Basel). 2021 Apr 2;10(4):551. doi: 10.3390/antiox10040551.
has been used as a food and traditional medicines. However, most of research on discovering bioactive constituents from this plant have been focused on its yellow fruit, Chinese quince, due to its wide usage. Here, we isolated and characterized three new phenolic compounds (, , and ) and 21 known compounds (-, , and -) from the twigs of . Their chemical structures were established by spectroscopic and spectrometric data analysis including 1D and 2D NMR, high-resolution mass spectrometry (HRMS), electronic circular dichroism (ECD), and LC-MS analysis. Some of the isolated compounds (-) showed anti-neuroinflammatory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, neurotrophic activity in C6 cells through the secretion of nerve growth factor (NGF) and/or cytotoxicity against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, MKN-1).
它已被用作食物和传统药物。然而，由于其广泛的用途，大多数从这种植物中发现生物活性成分的研究都集中在其黄色果实——榠楂上。在这里，我们从榠楂的嫩枝中分离并鉴定了三种新的酚类化合物（、和）以及21种已知化合物（-、、和-）。它们的化学结构通过光谱和光谱数据分析确定，包括一维和二维核磁共振、高分辨率质谱（HRMS）、电子圆二色性（ECD）和液相色谱-质谱分析。一些分离出的化合物（-）对脂多糖（LPS）激活的BV-2细胞中一氧化氮（NO）的产生具有抗神经炎症作用，通过分泌神经生长因子（NGF）对C6细胞具有神经营养活性和/或对四种人类癌细胞系（A549、SK-OV-3、SK-MEL-2、MKN-1）具有细胞毒性。
