Laboratoire de Chimie Durable et Santé, Health & Environment Department, Team Sustainable Chemistry, Ecole des Hautes Etudes d'Ingénieur (HEI), Yncréa Hauts-de-France, Lille, France.
Université de Technologie de Compiègne, ESCOM, Integrated Transformations of Renewable Matter, Centre de Recherche Royallieu, Compiègne, France.
Pest Manag Sci. 2021 May;77(5):2403-2414. doi: 10.1002/ps.6269. Epub 2021 Jan 21.
Research into environmentally friendly alternatives to conventional plant protection products, to promote sustainable agriculture and healthy food, is strongly encouraged.
In this context, 20 naturally occurring terpenoids and phenolic compounds were selected and evaluated in vitro as crop protection compounds against Zymoseptoria tritici, the causal agent of Septoria tritici blotch of wheat. After selection of the most active compounds, some hemisynthetic modifications were conducted to modify their lipophilicity. These modifications led to the discovery of sesamol esters as promising antifungal agents, with IC around 10 μg/mL and a total absence of cytotoxicity against human cells.
These sesamol-based derivatives should be selected for further evaluations in planta to validate their use as wheat crop protection agents. Moreover, the importance of a balanced hydrophily/lipophilicity ratio should be further studied. © 2021 Society of Chemical Industry.
鼓励开展研究，寻找环保型的传统植保产品替代品，以促进可持续农业和健康食品。
在这方面，选择了 20 种天然萜类化合物和酚类化合物，作为防治小麦叶枯病菌（引起小麦叶斑病的病原菌）的植保化合物在体外进行评估。在选择最有效的化合物后，对其进行了一些半合成修饰以改变其亲脂性。这些修饰发现芝麻酚酯类化合物是很有前途的抗真菌剂，IC 值约为 10 μg/mL，对人细胞完全没有细胞毒性。
这些基于芝麻酚的衍生物应被选中，进一步在植物体内进行评估，以验证其作为小麦植保剂的用途。此外，还应进一步研究亲水性/亲脂性平衡的重要性。 © 2021 英国化学学会。
