Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, United States.
ACS Infect Dis. 2021 Jun 11;7(6):1298-1302. doi: 10.1021/acsinfecdis.0c00874. Epub 2021 Jan 8.
The COVID-19 pandemic has generated an unprecedented response within the scientific community. Extraordinary efforts have been undertaken to identify potential new therapeutics to treat SARS-CoV-2 infection spanning traditional medicinal chemistry, repurposing, and computational approaches. The breadth of the effort and rapid progression of many small molecules to clinical testing provide an opportunity to determine what chemical and testing approaches have been the most efficient in identifying potential treatments and how this may inform preparation for future pandemics.
COVID-19 大流行在科学界引起了前所未有的反应。人们做出了非凡的努力，通过传统的药物化学、重新定位和计算方法来识别治疗 SARS-CoV-2 感染的潜在新疗法。这项工作的广度和许多小分子快速进入临床试验为确定哪些化学和测试方法在识别潜在治疗方法方面最有效以及如何为未来的大流行做好准备提供了机会。
