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Editorial: Antiviral drug discovery against pathogens of pandemic concern: Advancements in target site identification and structure-based drug development.

作者信息

Padmanabha Das Krishna M

机构信息

Department of Biological Chemistry and Molecular Pharmacology (BCMP), Harvard Medical School, Boston, MA, United States.

Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States.

出版信息

Front Mol Biosci. 2023 Mar 9;10:1165208. doi: 10.3389/fmolb.2023.1165208. eCollection 2023.

DOI:10.3389/fmolb.2023.1165208
PMID:36968270
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10034765/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f1f/10034765/f6b00e581a30/fmolb-10-1165208-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f1f/10034765/f6b00e581a30/fmolb-10-1165208-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f1f/10034765/f6b00e581a30/fmolb-10-1165208-g001.jpg

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本文引用的文献

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Nat Rev Mol Cell Biol. 2023 Jun;24(6):430-447. doi: 10.1038/s41580-022-00566-8. Epub 2023 Jan 3.
2
Improvement of native structure-based peptides as efficient inhibitors of protein-protein interactions of SARS-CoV-2 spike protein and human ACE2.基于天然结构的肽作为严重急性呼吸综合征冠状病毒2(SARS-CoV-2)刺突蛋白与人血管紧张素转换酶2(ACE2)蛋白质-蛋白质相互作用的高效抑制剂的改进。
Front Mol Biosci. 2022 Sep 28;9:983014. doi: 10.3389/fmolb.2022.983014. eCollection 2022.
3
In-silico investigation of systematic missense mutations of middle east respiratory coronavirus spike protein.
中东呼吸综合征冠状病毒刺突蛋白系统性错义突变的计算机模拟研究
Front Mol Biosci. 2022 Sep 14;9:933553. doi: 10.3389/fmolb.2022.933553. eCollection 2022.
4
Assessing the suitability of long non-coding RNAs as therapeutic targets and biomarkers in SARS-CoV-2 infection.评估长链非编码RNA作为新型冠状病毒感染治疗靶点和生物标志物的适用性。
Front Mol Biosci. 2022 Aug 16;9:975322. doi: 10.3389/fmolb.2022.975322. eCollection 2022.
5
Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19.网络药理学揭示了可重新用于治疗新冠肺炎的药物的多靶点作用机制。
Front Pharmacol. 2022 Aug 17;13:952192. doi: 10.3389/fphar.2022.952192. eCollection 2022.
6
An oral SARS-CoV-2 M inhibitor clinical candidate for the treatment of COVID-19.一种用于治疗 COVID-19 的口服 SARS-CoV-2 M 抑制剂临床候选药物。
Science. 2021 Dec 24;374(6575):1586-1593. doi: 10.1126/science.abl4784. Epub 2021 Nov 2.
7
An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral.加拉西韦(BCX4430)作为一种广谱抗病毒药物的研究进展更新。
Antiviral Res. 2021 Nov;195:105180. doi: 10.1016/j.antiviral.2021.105180. Epub 2021 Sep 20.
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