Department of Chemistry & Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA 02138, USA; Chemical Biology & Therapeutics Science Program, Broad Institute, 415 Main St, Cambridge, MA 02142, USA.
Cell. 2021 Jan 7;184(1):3-9. doi: 10.1016/j.cell.2020.12.020.
2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen-as "molecular glues" that induce neo-protein-protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this story.
2021 年标志着环孢菌素 A 和 FK506 以一种以前从未见过的方式发挥作用的发现 30 周年——作为“分子胶”诱导新的蛋白-蛋白相互作用。随着大量新的分子胶探针和药物激发了人们对该领域的兴趣，我探讨了这个故事的发展轨迹。
