免疫抑制剂FK506和环孢素对小鼠全身性白色念珠菌感染的影响。
Influences of immunosuppressive agents, FK506 and cyclosporin on systemic Candida albicans infection in mice.
作者信息
Ito E, Tanaka Y
机构信息
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
出版信息
Mycopathologia. 1997;138(2):57-64. doi: 10.1023/a:1006827828838.
The effects of the immunosuppressive agents FK506 (tacrolimus) and cyclosporin (CyA) on Candida albicans infection in mice were compared with those of cyclophosphamide. FK506 and CyA did not exacerbate C. albicans infection in mice when the effects were determined on the basis of survival ratio and colony forming units (CFU) in the kidney, although cyclophosphamide (CY) impaired the host defence mechanisms of mice against C. albicans infection. The effects of FK506 and CyA on the body weight of mice, histopathological changes of lymphoid tissues and formation of granulomas in kidney were also studied in comparison with those of CY.
将免疫抑制剂FK506（他克莫司）和环孢素（CyA）对小鼠白色念珠菌感染的影响与环磷酰胺的影响进行了比较。当根据小鼠的存活率和肾脏中的菌落形成单位（CFU）来确定影响时，FK506和CyA不会加重小鼠的白色念珠菌感染，尽管环磷酰胺（CY）损害了小鼠对抗白色念珠菌感染的宿主防御机制。还将FK506和CyA对小鼠体重、淋巴组织的组织病理学变化以及肾脏肉芽肿形成的影响与CY的影响进行了比较研究。
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