FINCHES: A Computational Framework for Predicting Intermolecular Interactions in Intrinsically Disordered Proteins.

This comprehensive review examines FINCHES (Force field-based Interaction Network for Characterizing Heterotypic and Entropic Sequences). This groundbreaking computational framework enables the rapid, sequence-based prediction of intermolecular interactions in intrinsically disordered regions (IDRs) without the need for molecular simulations. The document provides detailed comparisons with other computational methods, including their mathematical foundations, specific applications, and experimental validations. We explore both the potential for advancing our understanding of disordered protein function and the inherent challenges in computationally modeling these dynamic biological systems. Additionally, we discuss computational assessment tools for interface prediction in molecular complexes, providing a comprehensive framework for evaluating IDR interaction predictions.