Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Mengla, Yunnan, 666303, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Mengla, Yunnan, 666303, China.
Phytochemistry. 2021 Mar;183:112651. doi: 10.1016/j.phytochem.2020.112651. Epub 2021 Jan 5.
Eleven previously uncharacterized steroids, along with three analogs were isolated from Aglaia lawii leaves. Their structures were definitely characterized by the methods of NMR, MS, IR, ECD and X-ray crystallography study. Among these unreported compounds, 3-epi-dyscusin C, 3-epi-lansisterone E and (Z)-2α-hydroxyaglawone were C-21 pregnane steroids incorporating a highly oxygenated ring A, while others were Δ-3β-hydroxy-7-ketosteroids bearing different ring D and C-17 aliphatic chains. All isolates were evaluated for nitric oxide (NO) inhibitory activities. 3-Epi-dyscusin C, 3-epi-lansisterone E, (Z)-2α-hydroxyaglawone and 17(20)E-dyscusin B showed significant anti-inflammatory activities with IC values of NO inhibition less than 10 μM (in the range from 4.47 ± 0.36 to 7.67 ± 0.46 μM).
从细叶龙船花 Aglaia lawii 的叶子中分离得到了 11 种以前未被描述的甾体化合物，以及 3 种类似物。通过 NMR、MS、IR、ECD 和 X 射线晶体学研究的方法，明确地确定了它们的结构。在这些未报道的化合物中，3-表二去甲胆甾酮 C、3-表兰甾体酮 E 和（Z）-2α-羟基阿格劳龙为含有高度氧化 A 环的 C-21 孕甾烷甾体，而其他则为具有不同环 D 和 C-17 脂肪链的 Δ-3β-羟基-7-酮甾体。所有分离物均进行了一氧化氮（NO）抑制活性评估。3-表二去甲胆甾酮 C、3-表兰甾体酮 E、（Z）-2α-羟基阿格劳龙和 17(20)E-二去甲胆甾酮 B 表现出显著的抗炎活性，其 NO 抑制的 IC 值小于 10 μM（范围为 4.47±0.36 至 7.67±0.46 μM）。
