Qiu S X, Nguyen V H, Le T X, Gu J Q, Lobkovsky E, Tran C K, Soejarto D D, Clardy J, Pezzuto J M, Dong Y, Mai V T, Le M H, Fong H H
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, USA.
Phytochemistry. 2001 Apr;56(7):775-80. doi: 10.1016/s0031-9422(00)00463-5.
The pregnane steroid, (E)-aglawone, along with four known triterpenes, and a known sterol mixture were isolated from the bark of Aglaia lawii (Wight) Saldanha ex Ramamoorty (Meliaceae). The structural determination/identification was accomplished by a combination of 1D- and 2D-NMR spectroscopic techniques. The relative stereochemistry of the known triterpene, 20S,24S-epoxydammarane-3alpha,25-diol acetate, was also unequivocally determined for the first time by X-ray crystallography. The isolates were not active against various human cancer cell lines.
从（楝科）拉维格米仔兰（Aglaia lawii (Wight) Saldanha ex Ramamoorty）的树皮中分离出孕甾类固醇（E）-阿格劳酮、四种已知的三萜类化合物以及一种已知的甾醇混合物。通过一维和二维核磁共振光谱技术相结合完成了结构测定/鉴定。已知的三萜类化合物20S，24S-环氧达玛烷-3α，25-二醇乙酸酯的相对立体化学也首次通过X射线晶体学明确确定。这些分离物对各种人类癌细胞系均无活性。
