The Wadsworth Center, New York State Department of Health, Albany, NY, USA.
The Wadsworth Center, New York State Department of Health, Albany, NY, USA.
Diagn Microbiol Infect Dis. 2021 Apr;99(4):115298. doi: 10.1016/j.diagmicrobio.2020.115298. Epub 2020 Dec 24.
The novel coronavirus outbreak caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) was first identified in December of 2019 in Wuhan, China. The local outbreak quickly rose to pandemic level that has spread to more than 188 countries with more than 19 million cases and 732,467 deaths worldwide. The current recommendation for testing is RT-PCR based tests of nasopharyngeal or alternatively nasal- and/or oropharyngeal swabs that detects infection with SARS-CoV-2 to diagnose acute infection. However, there is an urgent need for a quick and accurate antibody-based point-of-care test method to quickly identify evidence of SARS-CoV-2 infection among people who might be missed through active case finding and surveillance efforts. Serology tests measure the presence of antibodies in serum after infection. Here we compared the performance characteristics of 6 commercially available antibody-based point-of-care devices and their potential for identification of individuals infected at some time by SARS-CoV-2.
新型冠状病毒（SARS-CoV-2）引发的新型冠状病毒病疫情于 2019 年 12 月在中国武汉首次被发现。当地疫情迅速蔓延至全球 188 个国家，全球确诊病例超过 1900 万例，死亡超过 73.2467 万例。目前建议使用基于 RT-PCR 的鼻咽拭子或鼻咽拭子和/或口咽拭子检测，以检测 SARS-CoV-2 感染，从而诊断急性感染。然而，迫切需要一种快速、准确的基于抗体的即时检测方法，以便快速识别那些可能通过主动发现和监测而被遗漏的人群中的 SARS-CoV-2 感染证据。血清学检测在感染后测量血清中抗体的存在。在这里，我们比较了 6 种市售的基于抗体的即时检测设备的性能特征及其识别曾经感染过 SARS-CoV-2 的个体的潜力。
