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评估 SARS-CoV-2 抗体快速床边检测在家庭队列中的现场实用性。

Assessment of the Field Utility of a Rapid Point-of-Care Test for SARS-CoV-2 Antibodies in a Household Cohort.

机构信息

Institute of Global Health and Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

出版信息

Am J Trop Med Hyg. 2021 Nov 24;106(1):156-159. doi: 10.4269/ajtmh.21-0592.

DOI:10.4269/ajtmh.21-0592
PMID:34818625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8733539/
Abstract

Point-of-care (POC) tests to detect SARS-CoV-2 antibodies offer quick assessment of serostatus after natural infection or vaccination. We compared the field performance of the BioMedomics COVID-19 IgM/IgG Rapid Antibody Test against an ELISA in 303 participants enrolled in a SARS-CoV-2 household cohort study. The rapid antibody test was easily implemented with consistent interpretation across 14 users in a variety of field settings. Compared with ELISA, detection of seroconversion lagged by 5 to 10 days. However, it retained a sensitivity of 90% (160/177, 95% confidence interval [CI] 85-94%) and specificity of 100% (43/43, 95% CI 92-100%) for those tested 3 to 5 weeks after symptom onset. Sensitivity was diminished among those with asymptomatic infection (74% [14/19], 95% CI 49-91%) and early in infection (45% [29/64], 95% CI 33-58%). When used appropriately, rapid antibody tests offer a convenient way to detect symptomatic infections during convalescence.

摘要

即时检测（POC）用于检测 SARS-CoV-2 抗体，可在自然感染或接种疫苗后快速评估血清状态。我们比较了 BioMedomics COVID-19 IgM/IgG 快速抗体检测与 ELISA 在 303 名 SARS-CoV-2 家庭队列研究参与者中的现场性能。快速抗体检测易于实施，14 名使用者在各种现场环境中都有一致的解释。与 ELISA 相比，血清转换的检测滞后了 5 至 10 天。然而，对于症状出现后 3 至 5 周检测的患者，它仍保持了 90%（160/177，95%置信区间 [CI] 85-94%）的敏感性和 100%（43/43，95% CI 92-100%）的特异性。在无症状感染（74%[19/29]，95%CI 49-91%）和感染早期（45%[64/143]，95%CI 33-58%）患者中，敏感性降低。如果使用得当，快速抗体检测可以方便地在恢复期检测有症状的感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b37/8733539/e6997e3d49de/tpmd210592f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b37/8733539/ca8e8b821b6a/tpmd210592f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b37/8733539/17eb4374235a/tpmd210592f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b37/8733539/e6997e3d49de/tpmd210592f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b37/8733539/ca8e8b821b6a/tpmd210592f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b37/8733539/17eb4374235a/tpmd210592f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b37/8733539/e6997e3d49de/tpmd210592f3.jpg

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