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在 SARS-CoV-2 大流行期间实施妊娠缺铁的早期管理。

Implementation of early management of iron deficiency in pregnancy during the SARS-CoV-2 pandemic.

机构信息

University Hospitals Plymouth NHS Trust, Plymouth, Devon, PL6 8DH, United Kingdom.

East Kent Hospitals NHS Foundation Trust, William Harvey Hospital, Kennington Road, Willesborough, Ashford, Kent, TN24 0LZ, United Kingdom.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2021 Mar;258:60-62. doi: 10.1016/j.ejogrb.2020.12.055. Epub 2020 Dec 31.

Abstract

Iron deficiency is the commonest cause for anaemia worldwide making it a formidable issue particularly during pregnancy because of increased iron demands. This study looked at establishing a lower limit of normal for haemoglobin concentration (Hb) in our population and to proactively address potentially symptomatic iron deficiency during the current SARS-CoV-2 pandemic. The lower limit of normal for Hb in our 1715 first trimester pregnancy cohort was 116 g/L. This is in contrast with guidance suggesting Hb levels down to 110 g/L are normal. In addition there was evidence of limited testing performed to look for iron deficiency with only 18 % having a serum ferritin checked. Most anaemia was normocytic suggesting that microcytosis is only a late marker of iron deficiency lacking sensitivity. A strategy to avoid hospital contact during the COVID-19 pandemic is proposed.

摘要

缺铁是全球范围内最常见的贫血原因,这是一个严峻的问题,尤其是在怀孕期间,因为铁的需求量增加。本研究旨在确定我们人群中血红蛋白浓度(Hb)的正常下限,并在当前 SARS-CoV-2 大流行期间积极解决潜在的有症状缺铁问题。我们的 1715 名孕早期妊娠队列的 Hb 正常下限为 116g/L。这与建议 Hb 水平低至 110g/L 仍属正常的指南形成对比。此外,仅有 18%的人进行了血清铁蛋白检查,这表明检查缺铁的检测手段有限。大多数贫血为正细胞性,表明小细胞症只是缺铁的晚期标志物,缺乏敏感性。提出了一种在 COVID-19 大流行期间避免医院接触的策略。

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引用本文的文献

本文引用的文献

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UK guidelines on the management of iron deficiency in pregnancy.英国孕期缺铁管理指南。
Br J Haematol. 2020 Mar;188(6):819-830. doi: 10.1111/bjh.16221. Epub 2019 Oct 2.
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Prevalence of iron deficiency in first trimester, nonanemic pregnant women.孕早期非贫血孕妇缺铁的流行情况。
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How I treat anemia in pregnancy: iron, cobalamin, and folate.我如何治疗妊娠期贫血:铁、钴胺素和叶酸。
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Eur J Obstet Gynecol Reprod Biol. 2011 Nov;159(1):99-105. doi: 10.1016/j.ejogrb.2011.07.041. Epub 2011 Sep 3.
10
Iron status in pregnant women: which measurements are valid?孕妇的铁状态:哪些测量方法是有效的?
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