University Hospitals Plymouth NHS Trust, Plymouth, Devon, PL6 8DH, United Kingdom.
East Kent Hospitals NHS Foundation Trust, William Harvey Hospital, Kennington Road, Willesborough, Ashford, Kent, TN24 0LZ, United Kingdom.
Eur J Obstet Gynecol Reprod Biol. 2021 Mar;258:60-62. doi: 10.1016/j.ejogrb.2020.12.055. Epub 2020 Dec 31.
Iron deficiency is the commonest cause for anaemia worldwide making it a formidable issue particularly during pregnancy because of increased iron demands. This study looked at establishing a lower limit of normal for haemoglobin concentration (Hb) in our population and to proactively address potentially symptomatic iron deficiency during the current SARS-CoV-2 pandemic. The lower limit of normal for Hb in our 1715 first trimester pregnancy cohort was 116 g/L. This is in contrast with guidance suggesting Hb levels down to 110 g/L are normal. In addition there was evidence of limited testing performed to look for iron deficiency with only 18 % having a serum ferritin checked. Most anaemia was normocytic suggesting that microcytosis is only a late marker of iron deficiency lacking sensitivity. A strategy to avoid hospital contact during the COVID-19 pandemic is proposed.
缺铁是全球范围内最常见的贫血原因,这是一个严峻的问题,尤其是在怀孕期间,因为铁的需求量增加。本研究旨在确定我们人群中血红蛋白浓度(Hb)的正常下限,并在当前 SARS-CoV-2 大流行期间积极解决潜在的有症状缺铁问题。我们的 1715 名孕早期妊娠队列的 Hb 正常下限为 116g/L。这与建议 Hb 水平低至 110g/L 仍属正常的指南形成对比。此外,仅有 18%的人进行了血清铁蛋白检查,这表明检查缺铁的检测手段有限。大多数贫血为正细胞性,表明小细胞症只是缺铁的晚期标志物,缺乏敏感性。提出了一种在 COVID-19 大流行期间避免医院接触的策略。