Wen Jianchuan, Yeh Chih-Ko, Sun Yuyu
Department of Chemistry, University of Massachusetts Lowell, 1 University Avenue, Lowell, Massachusetts 01854, United States.
Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, and Geriatric Research Education and Clinical Center, Audie L. Murphy Division, South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229, United States.
ACS Biomater Sci Eng. 2016 Feb 8;2(2):224-230. doi: 10.1021/acsbiomaterials.5b00416. Epub 2016 Jan 7.
Colonization and biofilm-formation of species on denture surfaces cause -associated denture stomatitis (CADS), a recurring fungal infection that affects up to 67% of denture wearers. We grafted poly(2-hydroxyethyl methacrylate) (PHEMA) onto poly(methyl methacrylate) (PMMA)-based denture resins through plasma-initiated grafting polymerization. The effects of reaction conditions on grafting and the physical properties of the resulting resins were evaluated. The grafted resins showed significantly increased drug binding capability toward clotrimazole, one of the most widely used antifungal drugs. The mechanisms for the enhancement in drug binding were discussed. The new clotrimazole-containing resins provided sustained drug release for longer than 28 days, and the released drugs demonstrated potent, long-term biofilm-controlling effects against , pointing to an attractive strategy in controlling CADS and related fungal infections.
假牙表面微生物的定植和生物膜形成会导致义齿性口炎（CADS），这是一种复发性真菌感染，影响高达67%的假牙佩戴者。我们通过等离子体引发的接枝聚合将聚（甲基丙烯酸2-羟乙酯）（PHEMA）接枝到聚甲基丙烯酸甲酯（PMMA）基假牙树脂上。评估了反应条件对接枝和所得树脂物理性能的影响。接枝树脂对最广泛使用的抗真菌药物之一克霉唑的药物结合能力显著增强。讨论了药物结合增强的机制。新型含克霉唑树脂提供了超过28天的持续药物释放，并且释放的药物对[此处原文缺失具体微生物名称]表现出有效的长期生物膜控制作用，这为控制CADS和相关真菌感染提供了一种有吸引力的策略。
