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一种用于治疗义齿性口腔念珠菌病的新型抗真菌药物口腔内给药形式。

A new form of intraoral delivery of antifungal drugs for the treatment of denture-induced oral candidosis.

作者信息

Amin Wala M, Al-Ali Muna H, Salim Nesreen A, Al-Tarawneh Sandra K

机构信息

Professor of Prosthodontics and Biomaterials, Dept. of Prosthetic Dentistry, Faculty of Dentistry, University of Jordan, Jordan.

出版信息

Eur J Dent. 2009 Oct;3(4):257-66.

PMID:19826596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2761155/
Abstract

OBJECTIVES

To monitor the release of the antifungal drugs Fluconazole, Chlorhexidine and a combination of the two from an auto-polymerized poly (methyl methacrylate) (PMMA) denture base resin; and to investigate the effect of the released drugs upon the growth of Candida albicans.

METHODS

A high performance liquid chromatography-Ultra violet (HPLC-UV) method was used in the analysis of the released drugs into distilled water from PMMA discs doped with the antifungal drugs Fluconazole (10%), Chlorhexidine (10%) and a combination of the two drugs (5% each). The antifungal efficacy of the released drugs was monitored, microbiologically, employing "well" technique on a Saborauds culture medium inoculated with a resistant strain of Candida albicans.

RESULTS

It was shown that Fluconazole, Chlorhexidine and the combination of the two drugs can be successfully incorporated with PMMA. It was found that the drugs leach steadily out of the PMMA resin into distilled water at mouth temperature and that sustained drug release continued throughout the 28 days test period. It was also shown that the released drugs demonstrated an antifungal activity against the resistant Candida albicans and this was most remarkable in the combined drugs samples.

CONCLUSIONS

The findings of this investigation have a clinical value in terms of their significant contribution to the treatment of fungal infections of the oral cavity. The sustained release of anti-fungal drugs from the PMMA resin clearly constitutes a new dosage form of these drugs via the poly (methyl methacrylate) delivery system.

摘要

目的

监测抗真菌药物氟康唑、氯己定以及二者组合从自聚聚甲基丙烯酸甲酯（PMMA）义齿基托树脂中的释放情况；并研究释放出的药物对白色念珠菌生长的影响。

方法

采用高效液相色谱 - 紫外（HPLC - UV）法分析从掺杂有抗真菌药物氟康唑（10%）、氯己定（10%）以及二者组合（各5%）的PMMA圆片中释放到蒸馏水中的药物。采用“孔”技术，在接种有白色念珠菌耐药菌株的沙氏培养基上，从微生物学角度监测释放药物的抗真菌效果。

结果

结果表明氟康唑、氯己定以及二者组合能够成功与PMMA结合。发现在口腔温度下，药物从PMMA树脂中稳定地渗出到蒸馏水中，并且在整个28天的测试期内持续释放。还表明释放出的药物对耐药白色念珠菌具有抗真菌活性，且在联合用药样品中最为显著。

结论

本研究结果对于口腔真菌感染的治疗具有重要临床价值，因其做出了显著贡献。通过聚甲基丙烯酸甲酯给药系统，抗真菌药物从PMMA树脂中的持续释放显然构成了这些药物的一种新剂型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/10b2fd9c3bd5/page_263_fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/dd45a13c0bfe/page_259_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/b6bccb639e9b/page_260_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/a9465ad964e6/page_260_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/f223f9f22b38/page_261_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/413e631f42e4/page_261_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/d357c1c4f4b1/page_261_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/bfc6ace71f22/page_261_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/c80fd133b1a7/page_262_fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/063d3707603f/page_262_fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/f1ccf068645e/page_262_fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/170ef29254a3/page_263_fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/10b2fd9c3bd5/page_263_fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/dd45a13c0bfe/page_259_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/b6bccb639e9b/page_260_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/a9465ad964e6/page_260_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/f223f9f22b38/page_261_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/413e631f42e4/page_261_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/d357c1c4f4b1/page_261_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/bfc6ace71f22/page_261_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/c80fd133b1a7/page_262_fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/063d3707603f/page_262_fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/f1ccf068645e/page_262_fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/170ef29254a3/page_263_fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/50a2/2761155/10b2fd9c3bd5/page_263_fig12.jpg

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