Henderson R P, Solomon C P
School of Pharmacy, Samford University, Birmingham, AL 35229.
Arch Intern Med. 1988 Mar;148(3):745-6.
The bile acid-binding resin cholestyramine was administered in a dose of 4 g every six hours to a patient with digoxin intoxication. The serum digoxin concentration declined rapidly, and the digoxin half-life decreased from 75.5 hours to 19.9 hours while cholestyramine was administered. All signs and symptoms of toxic reaction subsided during the period of cholestyramine therapy, which correlated with the decline in digoxin concentrations. Cholestyramine and a related agent, colestipol, presumably interrupt the enterohepatic recycling of digoxin to enhance elimination. These agents represent potentially useful adjunctive measures in the management of non-life-threatening digitalis intoxication.
给一名地高辛中毒患者每6小时服用4克胆汁酸结合树脂消胆胺。服用消胆胺期间，血清地高辛浓度迅速下降，地高辛半衰期从75.5小时降至19.9小时。消胆胺治疗期间，所有中毒反应的体征和症状均消失，这与地高辛浓度下降相关。消胆胺及相关药物考来替泊可能会中断地高辛的肠肝循环以促进其消除。这些药物是治疗非危及生命的洋地黄中毒潜在有用的辅助措施。
