Xi Juqun, Wang Wenjuan, Da Lanyue, Zhang Jingjing, Fan Lei, Gao Lizeng
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China.
Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.
ACS Biomater Sci Eng. 2018 Mar 12;4(3):1083-1091. doi: 10.1021/acsbiomaterials.7b00901. Epub 2018 Feb 8.
Imaging-guided diagnosis and therapy has been highlighted in the area of nanomedicines. However, integrating multiple functions with high performance in one theranostic ("all-in-one") still presents considerable challenges. Here, "all-in-one" nanoparticles with drug-loading capacity, catalase-mimetic activity, photoacoustic (PA) imaging ability and photothermal properties were prepared by decorating Au nanoparticles on doxorubicin (DOX) encapsulated poly(lactic--glycolic acid) (PLGA) vehicle. The results revealed that the as-prepared Au-PLGA hybrid nanoparticles possessed high photothermal conversion efficiency of up to approximately 69.0%, meanwhile their strong acoustic generation endowed them with efficient PA signal sensing for cancer diagnosis. On an 808 nm laser irradiation, the O generation, DOX release profile and reactive oxygen species (ROS) level were all improved, which were beneficial to relieving tumor hypoxia and enhanced the cancer chemo/PTT combined therapy. Overall, the multifunctional Au-PLGA hybrid nanoparticles with these integrated advantages shows promise in PA imaging-guided diagnosis and synergistic tumor ablation.
成像引导诊断与治疗在纳米医学领域已受到关注。然而，在单一的诊疗（“一体化”）中整合多种高性能功能仍面临巨大挑战。在此，通过在包封阿霉素（DOX）的聚乳酸-乙醇酸共聚物（PLGA）载体上修饰金纳米颗粒，制备了具有载药能力、过氧化氢酶模拟活性、光声（PA）成像能力和光热特性的“一体化”纳米颗粒。结果表明，所制备的金-聚乳酸-乙醇酸共聚物杂化纳米颗粒具有高达约69.0%的高光热转换效率，同时其强声学产生使其具备用于癌症诊断的高效光声信号传感能力。在808 nm激光照射下，氧气生成、阿霉素释放曲线和活性氧（ROS）水平均得到改善，这有利于缓解肿瘤缺氧并增强癌症化疗/光热治疗联合疗法。总体而言，具有这些综合优势的多功能金-聚乳酸-乙醇酸共聚物杂化纳米颗粒在光声成像引导诊断和协同肿瘤消融方面显示出前景。
