Breher Katharina, Calabuig Alejandro, Kühlewein Laura, Ziemssen Focke, Ohlendorf Arne, Wahl Siegfried
Institute for Ophthalmic Research, University of Tübingen, 72076 Tübingen, Germany.
Center for Ophthalmology, University of Tübingen, 72076 Tübingen, Germany.
J Clin Med. 2021 Jan 6;10(2):174. doi: 10.3390/jcm10020174.
Retinal shape presents a clinical parameter of interest for myopia, and has commonly been inferred indirectly from peripheral refraction (PRX) profiles. Distortion-corrected optical coherence tomography (OCT) scans offer a new and direct possibility for retinal shape estimation. The current study compared retinal curvatures derived from OCT scans vs. PRX measurements in three refractive profiles (0° and 90° meridians, plus spherical equivalent) for 25 participants via Bland-Altman analysis. The radial differences between both procedures were correlated to axial length using Pearson correlation. In general, PRX- and OCT-based retinal radii showed low correlation (all intraclass correlation coefficients < 0.21). PRX found flatter retinal curvatures compared to OCT, with the highest absolute agreement found with the 90° meridian (mean difference +0.08 mm) and lowest in the 0° meridian (mean difference +0.89 mm). Moreover, a negative relation between axial length and the agreement of both methods was detected especially in the 90° meridian (R = -0.38, = 0.06). PRX measurements tend to underestimate the retinal radius with increasing myopia when compared to OCT measurements. Therefore, future conclusions from PRX on retinal shape should be made cautiously. Rather, faster and more clinically feasible OCT imaging should be performed for this purpose.
视网膜形态是近视研究中一个重要的临床参数，通常通过周边屈光（PRX）曲线间接推断。经畸变校正的光学相干断层扫描（OCT）为视网膜形态评估提供了一种全新的直接方法。本研究通过Bland-Altman分析，比较了25名受试者在三种屈光曲线（0°和90°子午线，以及球镜等效值）下，OCT扫描与PRX测量所得的视网膜曲率。两种测量方法之间的径向差异通过Pearson相关分析与眼轴长度进行关联。总体而言，基于PRX和OCT的视网膜半径显示出较低的相关性（所有组内相关系数均<0.21）。与OCT相比，PRX测得的视网膜曲率更平坦，其中90°子午线的绝对一致性最高（平均差异+0.08mm），0°子午线最低（平均差异+0.89mm）。此外，尤其在90°子午线处检测到眼轴长度与两种方法一致性之间存在负相关（R = -0.38，P = 0.06）。与OCT测量相比，随着近视程度增加，PRX测量往往会低估视网膜半径。因此，基于PRX对视网膜形态得出的结论应谨慎。相反，为此目的应进行更快且临床可行性更高的OCT成像。
