Institute for Ophthalmic Research, Eberhard Karls University Tuebingen, 72076, Tübingen, Germany.
Carl Zeiss Vision International GmbH, 73430, Aalen, Germany.
Sci Rep. 2020 Jul 2;10(1):10886. doi: 10.1038/s41598-020-67940-4.
Myopic axial eye growth has mechanical implications on ocular structures, such as the retinal and foveal shape integrity or choroidal thickness. The current study investigated myopia-related changes of retinal radius of curvature, foveal width, depth, slope and choroidal thickness. Wide-field swept-source OCT line and volume scans were performed on 40 young adult participants in horizontal and vertical directions. OCT scans were corrected for their scan display distortions before automated extraction of retinal and foveal shape parameters. All findings were correlated to refractive error and axial length. The horizontal retinal radius of curvature and the directional ratio between horizontal and vertical retinal shape correlated significantly with axial length ([Formula: see text] and [Formula: see text]). Vertical retinal shape and foveal pit parameters neither showed any significant correlations with axial length nor refractive error (all [Formula: see text] 0.05). Choroidal thickness correlated significantly with refractive error in all analyzed regions ([Formula: see text]), but less with axial length ([Formula: see text] to - 0.37). Horizontal retinal shape and choroidal thickness, but not foveal pit morphology, were altered by myopic eye growth. Asymmetries in horizontal versus vertical retinal shape with increasing myopia were detected. These parameters could act as promising biomarkers for myopia and its associated complications.
近视轴向眼球生长对眼部结构有机械影响，例如视网膜和黄斑形状完整性或脉络膜厚度。本研究调查了与近视相关的视网膜曲率半径、黄斑宽度、深度、斜率和脉络膜厚度的变化。对 40 名年轻成年参与者进行了水平和垂直方向的宽场扫频源 OCT 线和体积扫描。在自动提取视网膜和黄斑形状参数之前，对 OCT 扫描进行了扫描显示失真校正。所有发现都与屈光不正和眼轴长度相关。水平视网膜曲率半径和水平与垂直视网膜形状之间的方向比与眼轴长度显著相关([Formula: see text]和[Formula: see text])。垂直视网膜形状和黄斑小凹参数与眼轴长度和屈光不正均无显著相关性（均[Formula: see text]0.05）。脉络膜厚度与所有分析区域的屈光不正显著相关([Formula: see text])，但与眼轴长度的相关性较小([Formula: see text]至-0.37)。水平视网膜形状和脉络膜厚度（而非黄斑小凹形态）因近视眼生长而发生改变。随着近视的增加，检测到水平与垂直视网膜形状之间的不对称。这些参数可以作为近视及其相关并发症的有前途的生物标志物。
