Departments of Physiology and Biophysics, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada.
Biomolecules. 2021 Jan 6;11(1):65. doi: 10.3390/biom11010065.
Lysosomes, the degradative endpoints and sophisticated cellular signaling hubs, are emerging as intracellular Ca stores that govern multiple cellular processes. Dys-homeostasis of lysosomal Ca is intimately associated with a variety of human diseases including cancer. Recent studies have suggested that the Ca-permeable channels Transient Receptor Potential (TRP) Mucolipins (TRPMLs, TRPML1-3) integrate multiple processes of cell growth, division and metabolism. Dysregulation of TRPMLs activity has been implicated in cancer development. In this review, we provide a summary of the latest development of TRPMLs in cancer. The expression of TRPMLs in cancer, TRPMLs in cancer cell nutrient sensing, TRPMLs-mediated lysosomal exocytosis in cancer development, TRPMLs in TFEB-mediated gene transcription of cancer cells, TRPMLs in bacteria-related cancer development and TRPMLs-regulated antitumor immunity are discussed. We hope to guide readers toward a more in-depth discussion of the importance of lysosomal TRPMLs in cancer progression and other human diseases.
溶酶体是降解终点和复杂的细胞信号枢纽，现作为细胞内钙库，调控多种细胞过程。溶酶体钙动态平衡失调与多种人类疾病密切相关，包括癌症。最近的研究表明，钙渗透性通道瞬时受体电位（TRP）多脂蛋白（TRPMLs，TRPML1-3）整合了细胞生长、分裂和代谢的多种过程。TRPMLs 活性失调与癌症的发展有关。在这篇综述中，我们总结了 TRPMLs 在癌症中的最新研究进展。讨论了 TRPMLs 在癌症中的表达、TRPMLs 在癌细胞营养感应中的作用、TRPMLs 介导的溶酶体胞吐作用在癌症发展中的作用、TRPMLs 在 TFEB 介导的癌细胞基因转录中的作用、TRPMLs 在与细菌相关的癌症发展中的作用以及 TRPMLs 调节的抗肿瘤免疫作用。我们希望引导读者更深入地讨论溶酶体 TRPMLs 在癌症进展和其他人类疾病中的重要性。
