Protogerou Vassilis, Chrysikos Dimosthenis, Karampelias Vasileios, Spanidis Ypatios, Sara El Bisari, Troupis Theodoros
Department of Anatomy, School of Medicine, National and Kapodistrian University of Athens, Mikras Asias 21 st, 12462 Athens, Greece.
3rd Urological Department, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Rimini 1, 124 62 Athens, Greece.
Medicines (Basel). 2021 Jan 6;8(1):2. doi: 10.3390/medicines8010002.
Erectile dysfunction (ED) is a disorder that affects the quality of life and the sexual relations of more than half of the male population aged over 40 years. The prediction regarding the incidence of ED is devastating as it is expected that this disorder will affect more than 300 million men in the next five years. Several studies have suggested the use of stem cells for the treatment of ED and showed that this type of treatment is promising in terms of damaged tissue repair as well as of clinical efficacy; however, there are several gaps in the knowledge and evidence is lacking. In order to highlight a few of them in this review, we performed a research of the literature focusing on currently available clinical studies regarding the clinical efficacy of stem cell administration for the treatment of ED. We reviewed the methods of administration, the cell types used in the performed clinical trials and the safety and efficiency of such procedures. We conclude that there are rapidly expanding and promising results from the reported clinical studies indicating that stem cells could indeed be a potential treatment for patients with ED although more studies are necessary.
勃起功能障碍(ED)是一种影响超过半数40岁以上男性人群生活质量和性关系的疾病。关于ED发病率的预测令人震惊,预计在未来五年内这种疾病将影响超过3亿男性。多项研究建议使用干细胞治疗ED,并表明这种治疗方式在受损组织修复以及临床疗效方面颇具前景;然而,在这方面仍存在一些知识空白且缺乏证据。为了在本综述中突出其中的一些问题,我们对文献进行了研究,重点关注目前关于干细胞给药治疗ED临床疗效的临床研究。我们回顾了给药方法、临床试验中使用的细胞类型以及这些程序的安全性和有效性。我们得出结论,已报道的临床研究有迅速扩展且前景良好的结果,表明干细胞确实可能是ED患者的一种潜在治疗方法,不过仍需要更多研究。