Moossy J, Zubenko G S, Martinez A J, Rao G R
Department of Pathology, University of Pittsburg School of Medicine, PA 15261.
Arch Neurol. 1988 Mar;45(3):251-4. doi: 10.1001/archneur.1988.00520270025015.
We studied 16 brains of patients with Alzheimer's disease for left-right differences, or similarities, in the density of senile plaques (SPs) or neurofibrillary tangles (NFTs). Counts were made of SPs and NFTs on the left and right side of five different brain areas, which included middle frontal, superior temporal, the prosubiculum of the hippocampus (HPR), the entorhinal cortex of the hippocampus (HEN), and the basal nucleus of Meynert. The density of SPs was bilaterally symmetrical in all regions except the basal nucleus of Meynert in which technical problems may have occurred in sampling. In contrast to SPs, the density of NFTs was bilaterally symmetrical in both neocortical regions (middle frontal, superior temporal), but not in either hippocampal region (HPR, HEN). The absence of bilateral symmetry for the density of NFTs in the hippocampus, where the density of SPs was highly symmetrical, suggests that there may be a different pathogenesis for these lesions in Alzheimer's disease. The lack of a significant correlation between SP and NFT density within four of five regions, including HPR and HEN, also supports this suggestion.
我们研究了16例阿尔茨海默病患者的大脑，以观察老年斑（SPs）或神经原纤维缠结（NFTs）密度的左右差异或相似性。对五个不同脑区的左右两侧的SPs和NFTs进行计数，这五个脑区包括额中回、颞上回、海马的前下托（HPR）、海马的内嗅皮质（HEN）以及Meynert基底核。除Meynert基底核外，所有区域的SPs密度在两侧都是对称的，在Meynert基底核可能在采样过程中出现了技术问题。与SPs相反，NFTs密度在两个新皮质区域（额中回、颞上回）两侧对称，但在两个海马区域（HPR、HEN）均不对称。在SPs密度高度对称的海马区，NFTs密度缺乏双侧对称性，这表明在阿尔茨海默病中这些病变可能存在不同的发病机制。包括HPR和HEN在内的五个区域中的四个区域内，SPs与NFTs密度之间缺乏显著相关性，这也支持了这一观点。
