Jabs D A, Hanneken A M, Schachat A P, Fine S L
Uveitis and Clinical Immunology Service, Wilmer Ophthalmological Institute, Baltimore, MD 21205.
Arch Ophthalmol. 1988 Feb;106(2):230-4. doi: 10.1001/archopht.1988.01060130240036.
Choroidopathy in association with systemic lupus erythematosus (SLE) is a clinically unusual manifestation, previously described in only six patients, to our knowledge. We have followed up six patients with SLE and choroidopathy manifested by multifocal, serous elevations of the retinal pigment epithelium and sensory retina. In four patients, macular involvement was present, and they suffered visual loss. Two eyes of two patients progressed to large, bullous, exudative retinal detachments. In the three patients in whom control of the systemic disease was achieved, the serous detachments resolved. The pathogenesis is most likely related to choroidal vascular disease with resultant pigment epithelial damage and serous fluid leakage beneath the retina.
与系统性红斑狼疮（SLE）相关的脉络膜病变是一种临床上不常见的表现，据我们所知，此前仅在6例患者中有所描述。我们对6例患有脉络膜病变的SLE患者进行了随访，这些患者表现为视网膜色素上皮和感觉视网膜的多灶性浆液性隆起。4例患者出现黄斑受累，并伴有视力丧失。2例患者的2只眼睛进展为巨大的、大疱性渗出性视网膜脱离。在3例实现系统性疾病控制的患者中，浆液性脱离得到缓解。其发病机制很可能与脉络膜血管疾病有关，导致色素上皮损伤和视网膜下浆液性液体渗漏。
