The Institute for Integrative Genome Biology, University of California at Riverside, Riverside, CA, U.S.A.;
The Institute for Integrative Genome Biology, University of California at Riverside, Riverside, CA, U.S.A.
Cancer Genomics Proteomics. 2021 Jan-Feb;18(1):43-52. doi: 10.21873/cgp.20240.
Numerous cancer drivers have been identified, but they are specific to a given cancer type and condition; universal cancer drivers and universal cancer mechanisms still remain largely unclear. Here, we identified the deadliest universal drivers for all cancers via developing algorithms to analyze massive RNAseqs and clinical data from The Cancer Genome Atlas (TCGA). In general, noncoding RNAs primarily serve as the most important inducers and suppressors for all types of cancers. In particular, pseudogenes are primary inducers, and specifically the antisense RNA RP11-335K5.2 serves as the most universal cancerous driver, independently of the cancer type and condition. Therefore, noncoding RNAs, instead of proteins as conventionally thought, primarily drive cancer, which establishes a novel field for future cancer research and therapy.
已经发现了许多癌症驱动因素，但它们是特定于给定的癌症类型和状况的；普遍的癌症驱动因素和普遍的癌症机制仍然很大程度上不清楚。在这里，我们通过开发算法来分析来自癌症基因组图谱（TCGA）的大量 RNAseq 和临床数据，确定了所有癌症的最致命的普遍驱动因素。一般来说，非编码 RNA 主要作为所有类型癌症的最重要的诱导剂和抑制剂。特别是假基因是主要的诱导剂，特别是反义 RNA RP11-335K5.2 作为最普遍的致癌驱动因素，独立于癌症类型和状况。因此，非编码 RNA，而不是蛋白质，主要驱动癌症，这为未来的癌症研究和治疗开辟了一个新的领域。
