White Rachel, Stanley Fintan, Than Jen, Macnair Archie, Pethick Joanna, Fallica Gregory, Hounsome Luke, Maher Jane
Macmillan Cancer Support, London, UK
Macmillan Cancer Support, London, UK.
BMJ Open. 2021 Jan 8;11(1):e040808. doi: 10.1136/bmjopen-2020-040808.
This study estimates the prevalence of cancers that are categorised as treatable but not curable (TbnC) in England. It provides a quantification of the population and a framework to aid identification of this group to enable the design of tailored support services.
Through consultation with clinical and data experts an algorithmic definition of TbnC was developed. Using cancer registry data sets, with five other linked data sets held by the National Disease Registration Service, the algorithm was applied as part of this retrospective cohort study to estimate the size and characteristics of the TbnC population.
The health data records of 1.6 million people living with cancer in England in 2015, following a cancer diagnosis between 2001 and 2015, were retrospectively assessed for TbnC status.
An estimated 110 615 people in England were living with TbnC cancer at the end of 2015, following identification of TbnC cancer between 2012 and 2015. In addition, 51 946 people fit the initial search criteria but were found to have been in their last year of life at the end of 2015 and therefore considered separately here as end of life cases. A further 57 117 people in England were initially identified as being at high risk of recurrence or having their life being shortened by cancer but did not fit the TbnC conceptual framework and were excluded, but their results are also reported under 'group B'.
A population living with TbnC cancer can be identified using data currently collected on a national scale in England. This large population living with TbnC cancer requires personalised treatment and support.
本研究估计了英格兰被归类为可治疗但不可治愈（TbnC）癌症的患病率。它提供了对这一人群的量化以及一个有助于识别该群体的框架，以便设计量身定制的支持服务。
通过与临床和数据专家协商，制定了TbnC的算法定义。利用癌症登记数据集以及国家疾病登记服务机构持有的其他五个关联数据集，该算法被应用于这项回顾性队列研究，以估计TbnC人群的规模和特征。
对2001年至2015年间被诊断患有癌症的160万英格兰癌症患者的健康数据记录进行回顾性评估，以确定其TbnC状态。
在2012年至2015年间确诊为TbnC癌症后，估计2015年底英格兰有110615人患有TbnC癌症。此外，有51946人符合初始搜索标准，但在2015年底被发现处于生命的最后一年，因此在此单独作为临终病例考虑。英格兰还有57117人最初被确定为复发风险高或因癌症而生命缩短，但不符合TbnC概念框架，因此被排除在外，但其结果也在“B组”下报告。
利用英格兰目前在全国范围内收集的数据，可以识别出患有TbnC癌症的人群。这一大量患有TbnC癌症的人群需要个性化的治疗和支持。
