Department of Obstetrics and Gynecology, Northwest Women's and Children's Hospital, Xi'an, 710061, China.
Department of Nutrition and Food Safety, School of Public Health, Xi'an Jiaotong University, Xi'an, 710061, China.
Eur J Epidemiol. 2021 Feb;36(2):223-232. doi: 10.1007/s10654-020-00704-6. Epub 2021 Jan 9.
The large-scale Xi'an longitudinal mother-child cohort study has started to enroll pregnant women who attended Northwest Women's and Children's Hospital (NWCH) for antenatal care in early pregnancy (less than 20 weeks' gestation) from January 2013 and the enrollment will be ended in January 2023. We aimed to investigate the role of external factors (i.e., diet and environment) and internal (i.e., biological, genetic and epigenetic) on the short- and long-term outcomes of mothers and children up to at least 12 years. Mothers completed all routine prenatal care during pregnancy and four times of follow-up at 42 days, 3, 6 and 12 years after delivery, respectively. For children, birth information were obtained from routine medical records and the follow-up information were obtained from child health care clinics of NWCH at age 42 days, 6, 12 and 24 months, then by interviewing mothers every two years until 12 years old. A range of data (including biological, demographic, birth outcomes/birth defects and nutritional factors from both maternal and off-spring) were collected by both interviews and laboratory tests. By June 30th 2019, a total of 114,946 mothers and 124,454 live births had been recruited.
大型西安纵向母婴队列研究已开始招募于 2013 年 1 月在孕早期（<20 周妊娠）在西北妇女儿童医院（NWCH）接受产前检查的孕妇，并将于 2023 年 1 月结束招募。我们旨在研究外部因素（即饮食和环境）和内部因素（即生物、遗传和表观遗传）对母婴短期和长期结局的影响，研究将持续至少 12 年。母亲在怀孕期间完成所有常规产前检查，并在产后 42 天、3、6 和 12 年时分别进行 4 次随访。对于儿童，出生信息从常规医疗记录中获得，随访信息从 NWCH 的儿童保健诊所获得，在 42 天、6、12 和 24 个月时获得，然后通过每两年对母亲进行一次访谈，直到 12 岁。通过访谈和实验室测试收集了一系列数据（包括母婴的生物、人口统计学、出生结局/出生缺陷和营养因素）。截至 2019 年 6 月 30 日，共招募了 114946 名母亲和 124454 名活产儿。
