Li Xiangyu, Wu Ying, Yi Bin, Chen Mengjie, Zhang Gang, Shao Xiaoshan, Jiang Xiulian, Cui Yuxia, Chen Li, Dong Xiaojing, Zhang Shu, Zhao Yao, Deng Yuebi, Li Xueqi, Wang Yang, Wu Lei, Fu Yu, Ran Dan, Peng Chen, Yang Xiao, Zhang Lan, Wang Yanxia, Zhu Yi, Sun Dina, Ran Yuchen, Zheng Dan, Yin Xuan, Chen Yufen, Long Yu, Wang Wenjing, Zhao Xiaodong, Liu Enmei, Xu Tao, Li Qiu, Zhong Wen
Department of Early Life Development and Cohort Research Laboratory Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Municipal Health Commission Key Laboratory of Children's Vital Organ Development and Diseases Chongqing China.
Guangzhou National Laboratory Guangzhou China.
Imeta. 2025 May 26;4(3):e70049. doi: 10.1002/imt2.70049. eCollection 2025 Jun.
The Western China Birth Cohort (WCBC) is a large-scale, multi-centered, prospective birth cohort study designed to address critical gaps in maternal and child health research in Western China, a region with diverse altitudes, ethnic groups, and unique environmental exposures. WCBC had enrolled 15,093 pregnant women across eight clinical centers in five provinces (Qinghai, Gansu, Guizhou, Chongqing, and Sichuan), spanning from the high-altitude Qinghai-Tibet Plateau to lowland regions. WCBC has collected over 220,000 medical records, 80,000 questionnaires, and 12 different types of biological samples, including peripheral blood, cord blood, dried blood spots, placenta, umbilical cord, decidua, saliva, feces, throat and nasal swabs, vaginal swabs, and breast milk. By integrating advanced multi-omics measurement, including genomics, proteomics, exosome profiling, metabolomics, spatial transcriptomics, single-cell RNA sequencing, culturome, metagenomics, and virosome analysis, WCBC provides a valuable platform to explore gene-environment interplay, early-life determinants of health, and long-term disease risks in diverse populations in Western China.
中国西部出生队列（WCBC）是一项大规模、多中心的前瞻性出生队列研究，旨在填补中国西部母婴健康研究中的关键空白。中国西部地域广阔，海拔高度不同，民族多样，且存在独特的环境暴露因素。WCBC已在五个省份（青海、甘肃、贵州、重庆和四川）的八个临床中心招募了15,093名孕妇，研究范围涵盖了从高海拔的青藏高原到低地地区。WCBC已收集了超过220,000份医疗记录、80,000份调查问卷以及12种不同类型的生物样本，包括外周血、脐带血、干血斑、胎盘、脐带、蜕膜、唾液、粪便、咽喉和鼻拭子、阴道拭子以及母乳。通过整合先进的多组学测量方法，包括基因组学、蛋白质组学、外泌体分析、代谢组学、空间转录组学、单细胞RNA测序、培养组学、宏基因组学和病毒体分析，WCBC提供了一个宝贵的平台，用于探索中国西部不同人群中的基因-环境相互作用、健康的早期决定因素以及长期疾病风险。
