诺米芬辛、丙咪嗪与安慰剂重复给药对睡眠主观评估及精神运动表现客观测量的比较
Repeated dose comparison of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance.
作者信息
Hindmarch I, Parrott A C
出版信息
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):167S-173S. doi: 10.1111/j.1365-2125.1977.tb05747.x.
Abstract
- Nine normal subjects volunteered to participate in a randomized single-blind crossover study of nomifensine 75 mg and two comparators, imipramine 75 mg and placebo. 2. Each volunteer received placebo for 3 d, then the first test drug for 4 days. This sequence was repeated twice more, so that each subject received each comparator. All medication was taken three times daily. 3. Assessments were made on days 3, 5 and 7 of each sequence, and consisted of a Sleep Evaluation Questionnaire, a test of Critical Flicker Fusion and a measure of Complex Reaction Time (CRT). 4. There were no significant differences in the CRT. There was a significant increase in critical flicker fusion with nomifensine. 5. Although both nomifensine and imipramine disturbed the quality of sleep, only imipramine produced a hangover.
摘要
- 九名正常受试者自愿参与一项关于75毫克诺米芬辛以及两种对照药物（75毫克丙咪嗪和安慰剂）的随机单盲交叉研究。2. 每位志愿者先服用3天安慰剂，然后服用4天第一种试验药物。此顺序再重复两次，以便每位受试者都接受每种对照药物。所有药物均每日服用三次。3. 在每个疗程的第3、5和7天进行评估，评估内容包括睡眠评估问卷、临界闪烁融合测试和复合反应时间（CRT）测量。4. CRT方面无显著差异。诺米芬辛使临界闪烁融合显著增加。5. 尽管诺米芬辛和丙咪嗪都会干扰睡眠质量，但只有丙咪嗪会产生宿醉效应。
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