去甲丙咪嗪与酒精的动态相互作用。
Dynamic interaction of nomifensine with alcohol.
作者信息
Taeuber K
出版信息
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):147S-151S. doi: 10.1111/j.1365-2125.1977.tb05742.x.
Abstract
- Nine healthy volunteers participated in a comparative study of the effects of nomifensine, nomifensine plus alcohol, and placebo plus alcohol, on aspects of psychomotor performance. 2. The study was carried out according to a Latin square design and each treatment was separated from the preceding treatment by 7 days. 3. Placebo plus alcohol impaired performance, increased pulse rate and blood pressure, and increased feelings of activity and euphoria. 4. Nomifensine plus alcohol produced the same subjective and objective changes as placebo plus alcohol, but in no instance were changes any greater. 5. Nomifensine alone produced none of these changes. 6. It was concluded that single doses of nomifensine did not potentiate the effect of alcohol.
摘要
- 九名健康志愿者参与了一项关于诺米芬辛、诺米芬辛加酒精以及安慰剂加酒精对精神运动表现各方面影响的对比研究。2. 该研究按照拉丁方设计进行，每种治疗与前一种治疗间隔7天。3. 安慰剂加酒精会损害表现，增加脉搏率和血压，并增强活动感和欣快感。4. 诺米芬辛加酒精产生了与安慰剂加酒精相同的主观和客观变化，但在任何情况下变化都不会更大。5. 单独使用诺米芬辛不会产生这些变化。6. 得出的结论是，单剂量的诺米芬辛不会增强酒精的作用。
相似文献
1
Dynamic interaction of nomifensine with alcohol.去甲丙咪嗪与酒精的动态相互作用。
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):147S-151S. doi: 10.1111/j.1365-2125.1977.tb05742.x.
2
Pharmacodynamic comparison of the acute effects of nomifensine, amphetamine and placebo in healthy volunteers.
Int J Clin Pharmacol Biopharm. 1979 Jan;17(1):32-7.
3
Repeated dose comparison of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance.诺米芬辛、丙咪嗪与安慰剂重复给药对睡眠主观评估及精神运动表现客观测量的比较
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):167S-173S. doi: 10.1111/j.1365-2125.1977.tb05747.x.
4
Laboratory investigation of effect of acute doses of nomifensine on a simulated aspect of night-time car driving performance.急性剂量的诺米芬辛对模拟夜间汽车驾驶性能影响的实验室研究。
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):175S-178S. doi: 10.1111/j.1365-2125.1977.tb05748.x.
5
Interaction of alcohol with maprotiline or nomifensine: echocardiographic and psychometric effects.酒精与马普替林或诺米芬辛的相互作用：超声心动图和心理测量学效应。
Eur J Clin Pharmacol. 1988;35(6):593-9. doi: 10.1007/BF00637594.
6
A comparison of the pharmacodynamic profiles of nomifensine and amitriptyline in normal subjects.正常受试者中诺米芬辛与阿米替林药效学特征的比较。
Br J Clin Pharmacol. 1980 Mar;9(3):247-53. doi: 10.1111/j.1365-2125.1980.tb04834.x.
7
[Nomifensine: clinical data (author's transl)].[诺米芬辛：临床数据（作者译）]
Nouv Presse Med. 1978 Jun 28;7(26):2295-304.
8
Proceedings: Interaction between nomifensine and alcohol in normal subjects.
Arzneimittelforschung. 1976;26(6):1261-2.
9
Effects of bupropion, nomifensine and dexamphetamine on performance, subjective feelings, autonomic variables and electroencephalogram in healthy volunteers.安非他酮、诺米芬辛和右旋苯丙胺对健康志愿者的行为表现、主观感受、自主神经变量及脑电图的影响。
Br J Clin Pharmacol. 1983 Mar;15(3):367-74. doi: 10.1111/j.1365-2125.1983.tb01512.x.
引用本文的文献
1
Psychomotor function and psychoactive drugs.精神运动功能与精神活性药物。
Br J Clin Pharmacol. 1980 Sep;10(3):189-209. doi: 10.1111/j.1365-2125.1980.tb01745.x.
2
An evaluation of possible interactions between ethanol and trazodone or amitriptyline.乙醇与曲唑酮或阿米替林之间可能的相互作用评估。
Br J Clin Pharmacol. 1984 Oct;18(4):549-57. doi: 10.1111/j.1365-2125.1984.tb02503.x.
3
Interaction of alcohol with maprotiline or nomifensine: echocardiographic and psychometric effects.酒精与马普替林或诺米芬辛的相互作用：超声心动图和心理测量学效应。
Eur J Clin Pharmacol. 1988;35(6):593-9. doi: 10.1007/BF00637594.
4
Evaluation and comparison of the interaction between alcohol and moclobemide or clomipramine in healthy subjects.健康受试者中酒精与吗氯贝胺或氯米帕明相互作用的评估与比较。
Psychopharmacology (Berl). 1990;100(1):40-5. doi: 10.1007/BF02245787.
5
Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness.诺米芬辛：其药理特性及对抑郁症治疗效果的综述
Drugs. 1979 Jul;18(1):1-24. doi: 10.2165/00003495-197918010-00001.
6
Kinetic and dynamic interaction of clobazam and alcohol.氯巴占与酒精的动力学和动态相互作用。
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):91S-97S. doi: 10.1111/j.1365-2125.1979.tb04672.x.
本文引用的文献
1
A comparison of the effect of imipramine, nomifensine, and placebo on the psychomotor performance of normal males.
Psychopharmacology (Berl). 1976 Dec 21;51(1):85-90. doi: 10.1007/BF00426327.
2
Laboratory investigation of effect of acute doses of nomifensine on a simulated aspect of night-time car driving performance.急性剂量的诺米芬辛对模拟夜间汽车驾驶性能影响的实验室研究。
Br J Clin Pharmacol. 1977;4Suppl 2(Suppl 2):175S-178S. doi: 10.1111/j.1365-2125.1977.tb05748.x.
Zotero 插件